CASP8AP2

From Wikipedia, the free encyclopedia

CASP8 associated protein 2

Identifiers

CASP8AP2; CED-4; FLASH; FLJ11208; KIAA1315; RIP25

External IDs

OMIM: 606880 MGI: 1349399 HomoloGene: 8066

Gene ontology
Molecular Function:	• transcription corepressor activity • death receptor binding • caspase activator activity • identical protein binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• transcription • regulation of transcription, DNA-dependent • apoptosis • caspase activation • signal transduction • induction of apoptosis via death domain receptors

Orthologs

Human

Mouse

Refseq

NM_012115 (mRNA)
NP_036247 (protein)

NM_011997 (mRNA)
NP_036127 (protein)

Location

Chr 6: 90.61 - 90.64 Mb

Chr 4: 32.94 - 32.98 Mb

Pubmed search

[1]

[2]

CASP8 associated protein 2, also known as CASP8AP2, is a human gene.^[1]

This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis.^[1]

[edit] References

^ ^a ^b Entrez Gene: CASP8AP2 CASP8 associated protein 2.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Imai Y, Kimura T, Murakami A, et al. (1999). "The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis.". Nature 398 (6730): 777–85. doi:10.1038/19709. PMID 10235259.
Koonin EV, Aravind L, Hofmann K, et al. (1999). "Apoptosis. Searching for FLASH domains.". Nature 401 (6754): 662; discussion 662–3. doi:10.1038/44317. PMID 10537104.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. PMID 10718198.
Choi YH, Kim KB, Kim HH, et al. (2001). "FLASH coordinates NF-kappa B activity via TRAF2.". J. Biol. Chem. 276 (27): 25073–7. doi:10.1074/jbc.M102941200. PMID 11340079.
Kino T, Chrousos GP (2003). "Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators.". J. Biol. Chem. 278 (5): 3023–9. doi:10.1074/jbc.M209234200. PMID 12477726.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Jun JI, Chung CW, Lee HJ, et al. (2005). "Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway.". Oncogene 24 (4): 688–96. doi:10.1038/sj.onc.1208186. PMID 15592525.
Kino T, Ichijo T, Chrousos GP (2005). "FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors.". J. Steroid Biochem. Mol. Biol. 92 (5): 357–63. doi:10.1016/j.jsbmb.2004.09.003. PMID 15698540.
Flotho C, Coustan-Smith E, Pei D, et al. (2006). "Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2.". Blood 108 (3): 1050–7. doi:10.1182/blood-2006-01-0322. PMID 16627760.
Barcaroli D, Bongiorno-Borbone L, Terrinoni A, et al. (2006). "FLASH is required for histone transcription and S-phase progression.". Proc. Natl. Acad. Sci. U.S.A. 103 (40): 14808–12. doi:10.1073/pnas.0604227103. PMID 17003125.
Barcaroli D, Dinsdale D, Neale MH, et al. (2006). "FLASH is an essential component of Cajal bodies.". Proc. Natl. Acad. Sci. U.S.A. 103 (40): 14802–7. doi:10.1073/pnas.0604225103. PMID 17003126.
Milovic-Holm K, Krieghoff E, Jensen K, et al. (2007). "FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies.". EMBO J. 26 (2): 391–401. doi:10.1038/sj.emboj.7601504. PMID 17245429.
Jeong EG, Lee SH, Lee HW, et al. (2007). "Immunohistochemical and mutational analysis of FLASH in gastric carcinomas.". APMIS 115 (8): 900–5. doi:10.1111/j.1600-0463.2007.apm_706.x. PMID 17696945.