CASC3

From Wikipedia, the free encyclopedia

Cancer susceptibility candidate 3

PDB rendering based on 2hyi.

Available structures: 2hyi, 2j0q, 2j0s, 2j0u

Identifiers

Symbol(s)

CASC3; BTZ; MLN51

External IDs

OMIM: 606504 MGI: 2179723 HomoloGene: 7208

Gene ontology
Molecular Function:	• molecular_function • identical protein binding
Cellular Component:	• cellular_component • nucleus • cytoplasm • ribonucleoprotein complex
Biological Process:	• transport • biological_process • intracellular mRNA localization • mRNA transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_007359 (mRNA)
NP_031385 (protein)

NM_138660 (mRNA)
NP_619601 (protein)

Location

Chr 17: 35.55 - 35.58 Mb

n/a

Pubmed search

[1]

[2]

Cancer susceptibility candidate 3, also known as CASC3, is a human gene.^[1]

The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles.^[1]

[edit] References

^ ^a ^b Entrez Gene: CASC3 cancer susceptibility candidate 3.

[edit] Further reading

Tomasetto C, Régnier C, Moog-Lutz C, et al. (1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.". Genomics 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069.
Varis A, Wolf M, Monni O, et al. (2002). "Targets of gene amplification and overexpression at 17q in gastric cancer.". Cancer Res. 62 (9): 2625–9. PMID 11980659.
Degot S, Régnier CH, Wendling C, et al. (2002). "Metastatic Lymph Node 51, a novel nucleo-cytoplasmic protein overexpressed in breast cancer.". Oncogene 21 (28): 4422–34. doi:10.1038/sj.onc.1205611. PMID 12080473.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Macchi P, Kroening S, Palacios IM, et al. (2003). "Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner.". J. Neurosci. 23 (13): 5778–88. PMID 12843282.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Palacios IM, Gatfield D, St Johnston D, Izaurralde E (2004). "An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay.". Nature 427 (6976): 753–7. doi:10.1038/nature02351. PMID 14973490.
Degot S, Le Hir H, Alpy F, et al. (2004). "Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module.". J. Biol. Chem. 279 (32): 33702–15. doi:10.1074/jbc.M402754200. PMID 15166247.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kim YK, Furic L, Desgroseillers L, Maquat LE (2005). "Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay.". Cell 120 (2): 195–208. doi:10.1016/j.cell.2004.11.050. PMID 15680326.
Ballut L, Marchadier B, Baguet A, et al. (2005). "The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.". Nat. Struct. Mol. Biol. 12 (10): 861–9. doi:10.1038/nsmb990. PMID 16170325.
Tange TØ, Shibuya T, Jurica MS, Moore MJ (2006). "Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.". RNA 11 (12): 1869–83. doi:10.1261/rna.2155905. PMID 16314458.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Shibuya T, Tange TØ, Stroupe ME, Moore MJ (2006). "Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay.". RNA 12 (3): 360–74. doi:10.1261/rna.2190706. PMID 16495234.
Andersen CB, Ballut L, Johansen JS, et al. (2006). "Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA.". Science 313 (5795): 1968–72. doi:10.1126/science.1131981. PMID 16931718.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Baguet A, Degot S, Cougot N, et al. (2007). "The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly.". J. Cell. Sci. 120 (Pt 16): 2774–84. doi:10.1242/jcs.009225. PMID 17652158.