Talk:Carcinoid syndrome

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I think that you should change the survival times--I was told that by a doctor at the Mayo Clinic in 2000 that the median survival from diagnosis was 7 years. If you check the online support groups you will hear of people surviving more than 20 years after diagnosis of liver metastases and onset of symptoms. --216.137.70.192 08:54, 7 January 2006. Moved from main article --82.16.57.133 19:59, 12 January 2006 (UTC)

The initial lines are also innaccurate - they state that carcinoid tumours occur in the G.I. tract but in fact they can also occur elsewhere e.g. the lung and even other organs. A very good source of information is www.carcinoid.org or www.netumoradvisor.org

There are inaccuracies in the pathophysiology section. Carcinoid tumors commonly make serotonin but not histamine or catecholamines. The vasoactive manifestations, most notably the flushing, result fromsecretion of kallekrein, the enzyme that catalyzes the conversion of kininogen to lysyl-bradykinin. The latter is further converted to bradykinin, one of the most powerful vasodilators known. Bradykinin, not serotonin, is the cause of the flushing.--BobL 18:36, 3 November 2006 (UTC)

[edit] detection

There are non-invasive imaging modalities for finding Carcinoid, including: Iodinated (I-123 or I-131) metaiodobenzylguanidine (MIBG), or Indium pentatreotide (>80% sensitivity). 66.57.77.120 02:27, 25 April 2007 (UTC)

- Question - I noticed during pathology lesson that, as you write in this article carcinoid tumors are yellow. Which substance in the cells causes the colour? My pathology professors had no answer, perhaps I should ask a biochemist... 81.209.175.112 18:20, 8 May 2007 (UTC)

[edit] how to naturally lower seratonin

Are there any ways to naturally lower seratonin? This disease and others are associated with high levels of seratonin and there should be some way to lower it naturally.

"Some patients with carcinoid may lack the metabolic machinery to convert serotonin to 5-HIAA, so they have high blood levels of serotonin but normal urinary 5-HIAA." writes the Cleveland Medical Clinic. <http://www.clevelandclinicmeded.com/diseasemanagement/endocrinology/flushing/flushing.htm> So basically, some people's bodies can't break down seratonin... and it adds up in their bodies. Would this be considered a genetic disease?

[edit] Carcinoid and Migraines

Has this occurred to anyone: -there is excessive vasodilation that occurs in carcinoid syndrome -there are new forms of migraine medicine called "triptans" that include medicine such as imitrex that have vasoconstrictive actions. -maybe that subject should be researched more and it seems that if you treat the person with vasoconstrictors it would improve some of the symptoms that carcinoid syndrome patients have that include frequent headaches.