Talk:Carbamazepine

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Hazard Codes Xn Risk Statements 22-42/43 Safety Statements 22-36/37/39 http://www.sigmaaldrich.com IUPAC:[5H-Dibenz[b,f]Azepine-5-Carboxamid]? log KOW 2.45 vaporpressure 1.84E-007 mm Hg at 25°C Löslichkeit in Wasser 17.7 mg/L

also seems to work at the voltage-gated ca+-channels [Rauth C. (2003): Stabilität von 99mTc-HMPAO: experimentelle Studien und Implikationen für die Epilepsie-Diagnostik]


Contents

[edit] Side Effects

"loss of platelets" is described in this article as both a "Common" side-effect and a "very rare" side-effect. It cannot be both, so which is it? --Colin Angus Mackay 12:33, 30 Mar 2005 (UTC)

According to the FDA labelling information (PDF) for Carbamazepine, loss of platelets is not listed as "most common" side-effect. A loss of platelets and/or white blood cells is said to be not uncommon, but the FDA lacks data on the more severe medical conditions of aplastic anemia and leukopenia, which are associated with decreased blood cell counts. I'll revise the article accordingly. -- Heath 66.32.1.24 06:49, 2 January 2006 (UTC)

I saw the auditory side effect mentioned in the article. About 10 years ago, I was on Tegretol for a few months for treatment of PTSD and depression (or whatever the psych doctor said I had) and I too noticed a difference in the pitch of numerous sounds. It was very hard to describe, but it was very noticeable to me. Has there ever been any research or other information brought up on possible causes of that particular side effect?

—Preceding unsigned comment added by Infinitrium (talk • contribs) 06:58, 6 July 2006

[edit] Interactions

Carbamazepine blood levels may be increased by verapamil, as well as by many other drugs, leading to possible toxicity. The Pill Book

My doctor proscribed verapamil, knowing that I was taking carbamazepine, and didn't warn me. I got weak, sick to the stomach for days; fried by UV rays (carbamazepine is photosensitizing); had double vision (I think because of dried out eyes); and nearly collapsed at work. Thank God for the Internet.

--OldMountainGoat 05:01, 3 June 2007 (UTC)

[edit] Reference

I tried to find the Schindler reference. Anyone seen it? JFW | T@lk 15:31, 24 October 2005 (UTC)

The paper you want is
Schindler, W. and Häfliger, F.: Über derivate des iminodibenzyls. Helv. Chim. Acta, 37, 472-483, 1954.
See the book "Drug Discovery: A Casebook and Analysis" by Robert A. Maxwell, Shohreh B. Eckhard. This was found using books.google.com.
--Colin 23:01, 21 November 2005 (UTC)

Colin, you're great. Thanks for that. JFW | T@lk 00:51, 22 November 2005 (UTC)

Is carbamazepine more effective in treating Herpes Zoster pain or Amitryptaline?

[edit] Effects on GABA?

The article mentions this drug's sodium channel effects, but according to a psychiatrist friend, it also has potent effects on GABA in the body (similar to gabapentin/Neurontin, he says), which apparently increases its efficacy as a mood stabilizer. Does anyone know specifically what those effects are, and could that information be added to the article? I submit that more people would be interested in the drug's effects on GABA, than explanations about sodium channels. Kel - Ex-web.god 13:02, 26 October 2007 (UTC)