Cardinal-Infante Afonso of Portugal

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Portuguese royalty
House of Aviz-Beja

Manuel I
Children include
   Miguel da Paz, Prince of Portugal and of Asturias
   João, Prince of Portugal (future John III)
   Isabella, Holy Roman Empress
   Infanta Beatriz, Duchess of Savoy
   Infante Luís, Duke of Beja
   Infante Fernando, Duke of Guarda and Trancoso
   Cardinal-Infante Afonso
   Henry I
   Infante Duarte, Duke of Guimarães
   Infanta Maria, Lady of Viseu
Grandchildren include
   Philip II of Spain and I of Portugal)
   Anthony I (illegitimate)
   Infanta Maria of Guimarães, Duchess of Parma and Piacenza
   Infanta Catarina of Guimarães, Duchess of Braganza
Great-Grandchildren include
   Teodósio II, Duke of Braganza
   Ranuccio I Farnese of Parma
Great-Great-Grandchildren include
   John II, Duke of Braganza (future John IV)
John III
Children include
   Maria Manuela, Princess of Portugal and of Asturias
   João Manuel, Prince of Portugal
Grandchildren include
   Sebastião, Prince of Portugal (future Sebastian I)
   Carlos, Prince of Asturias
Sebastian
Henry
Anthony (disputed king)

The Cardinal-Infante Afonso (15091540, Portuguese pronounced [ɐˈfõsu]; English: Alphonzo) was a Portuguese infante son of King Manuel I of Portugal and his wife Maria of Aragon.

Afonso was born in Évora on April 23, 1509 and during his life was made Cardinal of the Kingdom after occupying several religious positions throughout the country.

He died on April 21, 1540, in Lisbon and was buried in the See of Lisbon before he was moved to the Jerónimos Monastery.