Carboxyvinyl-carboxyphosphonate phosphorylmutase

From Wikipedia, the free encyclopedia

In enzymology, a carboxyvinyl-carboxyphosphonate phosphorylmutase (EC 2.7.8.23) is an enzyme that catalyzes the chemical reaction

1-carboxyvinyl carboxyphosphonate $\rightleftharpoons$ 3-(hydrohydroxyphosphoryl)pyruvate + CO₂

Hence, this enzyme has one substrate, 1-carboxyvinyl carboxyphosphonate, and two products, 3-(hydrohydroxyphosphoryl)pyruvate and CO₂.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is 1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating).

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2QIW.

[edit] References

IUBMB entry for 2.7.8.23
BRENDA references for 2.7.8.23 (Recommended.)
PubMed references for 2.7.8.23
PubMed Central references for 2.7.8.23
Google Scholar references for 2.7.8.23
Pollack SJ, Freeman S, Pompliano DL, Knowles JR (1992). "Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus". Eur. J. Biochem. 209: 735–43. doi:10.1111/j.1432-1033.1992.tb17342.x. PMID 1330557.
Anzai H, Murakami T, Imai S, Satoh A, Nagaoka K, Thompson CJ (1987). "Transcriptional regulation of bialaphos biosynthesis in Streptomyces hygroscopicus". J. Bacteriol. 169: 3482–8. PMID 3611020.