Carbon-monoxide dehydrogenase (acceptor)

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In enzymology, a carbon-monoxide dehydrogenase (acceptor) (EC 1.2.99.2) is an enzyme that catalyzes the chemical reaction

CO + H₂O + A $\rightleftharpoons$ CO₂ + AH₂

The 3 substrates of this enzyme are CO, H₂O, and A, whereas its two products are CO₂ and AH2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with other acceptors. The systematic name of this enzyme class is carbon-monoxide:acceptor oxidoreductase. Other names in common use include anaerobic carbon monoxide dehydrogenase, carbon monoxide oxygenase, carbon-monoxide dehydrogenase, and carbon-monoxide:(acceptor) oxidoreductase. This enzyme participates in methane metabolism. It has 4 cofactors: iron, Zinc, Nickel, and Iron-sulfur.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1JQK, 1MJG, 1N5W, 1N60, 1N61, 1N62, 1N63, 1OAO, 1SU6, 1SU7, 1SU8, 1SUF, and 1ZXI.

[edit] References

IUBMB entry for 1.2.99.2
BRENDA references for 1.2.99.2 (Recommended.)
PubMed references for 1.2.99.2
PubMed Central references for 1.2.99.2
Google Scholar references for 1.2.99.2
Bonam D, Ludden PW (1987). "Purification and characterization of carbon monoxide dehydrogenase, a nickel, zinc, iron-sulfur protein, from Rhodospirillum rubrum". J. Biol. Chem. 262: 2980–7. PMID 3029096.
Diekert G, Ritter M (1983). "Purification of the nickel protein carbon monoxide dehydrogenase of Clostridium thermoaceticum". FEBS. Lett. 151: 41–4. doi:10.1016/0014-5793(83)80338-X. PMID 6687458.
Drennan CL, Heo J, Sintchak MD, Schreiter E, Ludden PW (2001). "Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase". Proc. Natl. Acad. Sci. U. S. A. 98: 11973–8. doi:10.1073/pnas.211429998. PMID 11593006.
Dobbek H, Svetlitchnyi V, Gremer L, Huber R, Meyer O (2001). "Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster". Science. 293: 1281–5. doi:10.1126/science.1061500. PMID 11509720.