Carbamoyl phosphate synthetase

From Wikipedia, the free encyclopedia

Carbamoyl phosphate synthetase is an enzyme that catalyzes a reaction that produces carbamoyl phosphate. This enzyme catalyzes the reaction of ATP and bicarbonate to produce carbonyl phosphate and ADP. Carbonyl phosphate reacts with ammonia to give carbamate. In turn, carbamate reacts with a second ATP to give carbamoyl phosphate plus ADP.

There are two different forms that serve very different functions:

• Carbamoyl phosphate synthetase I (mitochondria, urea cycle)
• Carbamoyl phosphate synthetase II (cytosol, pyrimidine metabolism).

v • d • e Enzymes: ligases (EC 6) 6.1 - Carbon-Oxygen Aminoacyl tRNA synthetase 6.2 - Carbon-Sulfur Succinyl coenzyme A synthetase - Acetyl Co-A synthetase - Long fatty acyl CoA synthetase 6.3 - Carbon-Nitrogen Glutamine synthetase - Ubiquitin ligase (Von Hippel-Lindau tumor suppressor, UBE3A, Mdm2, Anaphase-promoting complex) - Glutathione synthetase - CTP synthase - Adenylosuccinate synthase - Argininosuccinate synthetase - Holocarboxylase synthetase - GMP synthase - Asparagine synthetase - Carbamoyl phosphate synthetase (I, II) - Gamma-glutamylcysteine synthetase 6.4 - Carbon-Carbon Carbon-carbon ligases 6.5 - Phosphoric Ester DNA ligase