Carbamoyl phosphate

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Carbamoyl phosphate
Identifiers
CAS number [590-55-6]
PubChem 278
MeSH Carbamoyl+phosphate
Properties
Molecular formula CH4NO5P
Molar mass 141.020 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Carbamoyl phosphate is an anion of biochemical significance. It is involved In ridding the body of excess nitrogen in the urea cycle, and also in the synthesis of pyrimidines.

It is produced from bicarbonate, ammonia, and phosphate, the latter derived from ATP. The synthesis is catalysed by the enzyme carbamoyl phosphate synthase, as follows:

  • HCO3- + ATP --> ADP + HO-C(O)-OPO3-2 (carbonyl phosphate)
  • HO-C(O)-OPO3-2 + NH3 + OH- → HPO42- + -O-C(O)NH2 + H2O
  • -O-C(O)NH2 + ATP → ADP + H2NC(O)OPO32-

[edit] See also

[edit] References

  • Nelson, David L. and Michael M. Cox. Lehninger Principles of Biochemistry fourth edition. W. H. Freeman and company New York.