CARD9

From Wikipedia, the free encyclopedia

Caspase recruitment domain family, member 9

Identifiers

CARD9; hCARD9

External IDs

OMIM: 607212 MGI: 2685628 HomoloGene: 14150

Gene ontology
Molecular Function:	• protein binding • protein homodimerization activity • CARD domain binding
Cellular Component:	• intracellular • cytoplasm
Biological Process:	• regulation of apoptosis • positive regulation of I-kappaB kinase/NF-kappaB cascade

Orthologs

Human

Mouse

n/a

Refseq

NM_052813 (mRNA)
NP_434700 (protein)

XM_285326 (mRNA)
XP_285326 (protein)

Location

n/a

Chr 2: 26.17 - 26.18 Mb

Pubmed search

[1]

[2]

Caspase recruitment domain family, member 9, also known as CARD9, is a human gene.^[1]

The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined.^[1]

[edit] References

^ ^a ^b Entrez Gene: CARD9 caspase recruitment domain family, member 9.

[edit] Further reading

Yang H, Minamishima YA, Yan Q, et al. (2008). "pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2.". Mol. Cell 28 (1): 15-27. doi:10.1016/j.molcel.2007.09.010. PMID 17936701.
Hsu YM, Zhang Y, You Y, et al. (2007). "The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens.". Nat. Immunol. 8 (2): 198-205. doi:10.1038/ni1426. PMID 17187069.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369-74. doi:10.1038/nature02465. PMID 15164053.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wang L, Guo Y, Huang WJ, et al. (2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.". J. Biol. Chem. 276 (24): 21405-9. doi:10.1074/jbc.M102488200. PMID 11259443.
Bertin J, Guo Y, Wang L, et al. (2001). "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B.". J. Biol. Chem. 275 (52): 41082-6. doi:10.1074/jbc.C000726200. PMID 11053425.