CARD8

From Wikipedia, the free encyclopedia

Caspase recruitment domain family, member 8

Identifiers

CARD8; CARDINAL; DACAR; DKFZp779L0366; KIAA0955; MGC57162; NDPP1; TUCAN

External IDs

Gene ontology
Molecular Function:	• protein binding • caspase activator activity • NACHT domain binding • protein homodimerization activity
Cellular Component:	• intracellular • nucleus • cytoplasm
Biological Process:	• regulation of apoptosis • negative regulation of I-kappaB kinase/NF-kappaB cascade • positive regulation of caspase activity • positive regulation of interleukin-1 beta secretion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_014959 (mRNA)
NP_055774 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 19: 53.4 - 53.45 Mb

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Pubmed search

[1]

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Caspase recruitment domain family, member 8, also known as CARD8, is a human gene.^[1]

Caspase recruitment domain (CARD)-containing proteins, such as CARD8, are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB; see MIM 164011) in the context of apoptosis or inflammation, respectively (Bouchier-Hayes et al., 2001).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: CARD8 caspase recruitment domain family, member 8.

[edit] Further reading

Fontalba A, Martinez-Taboada V, Gutierrez O, et al. (2007). "Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity.". J. Immunol. 179 (7): 4867–73. PMID 17878386.
Franke A, Rosenstiel P, Balschun T, et al. (2007). "No association between the TUCAN (CARD8) Cys10Stop mutation and inflammatory bowel disease in a large retrospective German and a clinically well-characterized Norwegian sample.". Gastroenterology 132 (5): 2080–1. doi:10.1053/j.gastro.2007.03.087. PMID 17484912.
McGovern DP, Butler H, Ahmad T, et al. (2006). "TUCAN (CARD8) genetic variants and inflammatory bowel disease.". Gastroenterology 131 (4): 1190–6. doi:10.1053/j.gastro.2006.08.008. PMID 17030188.
Checinska A, Giaccone G, Hoogeland BS, et al. (2006). "TUCAN/CARDINAL/CARD8 and apoptosis resistance in non-small cell lung cancer cells.". BMC Cancer 6: 166. doi:10.1186/1471-2407-6-166. PMID 16796750.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Agostini L, Martinon F, Burns K, et al. (2004). "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.". Immunity 20 (3): 319–25. PMID 15030775.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Stilo R, Leonardi A, Formisano L, et al. (2002). "TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation.". FEBS Lett. 521 (1-3): 165–9. PMID 12067710.
Zhang H, Fu W (2002). "NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-kappaB activation.". Int. J. Oncol. 20 (5): 1035–40. PMID 11956601.
Razmara M, Srinivasula SM, Wang L, et al. (2002). "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.". J. Biol. Chem. 277 (16): 13952–8. doi:10.1074/jbc.M107811200. PMID 11821383.
Bouchier-Hayes L, Conroy H, Egan H, et al. (2001). "CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways.". J. Biol. Chem. 276 (47): 44069–77. doi:10.1074/jbc.M107373200. PMID 11551959.
Pathan N, Marusawa H, Krajewska M, et al. (2001). "TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer.". J. Biol. Chem. 276 (34): 32220–9. doi:10.1074/jbc.M100433200. PMID 11408476.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63–70. PMID 10231032.