CARD11

From Wikipedia, the free encyclopedia


Caspase recruitment domain family, member 11
Identifiers
Symbol(s) CARD11; BIMP3; CARMA1; MGC133069
External IDs OMIM: 607210 MGI: 1916978 HomoloGene: 13024
Orthologs
Human Mouse
Entrez 84433 108723
Ensembl ENSG00000198286 ENSMUSG00000036526
Uniprot Q9BXL7 n/a
Refseq NM_032415 (mRNA)
NP_115791 (protein)		 XM_981066 (mRNA)
XP_986160 (protein)
Location Chr 7: 2.91 - 3.05 Mb Chr 5: 141.13 - 141.17 Mb
Pubmed search [1] [2]

Caspase recruitment domain family, member 11, also known as CARD11, is a human gene.[1]

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.[1]

[edit] References

  1. ^ a b Entrez Gene: CARD11 caspase recruitment domain family, member 11.

[edit] Further reading

  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549. 
  • "Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074. 
  • Wang L, Guo Y, Huang WJ, et al. (2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443. 
  • Bertin J, Wang L, Guo Y, et al. (2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692. 
  • Gaide O, Martinon F, Micheau O, et al. (2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation.". FEBS Lett. 496 (2-3): 121–7. PMID 11356195. 
  • Wang D, You Y, Case SM, et al. (2002). "A requirement for CARMA1 in TCR-induced NF-kappa B activation.". Nat. Immunol. 3 (9): 830–5. doi:10.1038/ni824. PMID 12154356. 
  • Gaide O, Favier B, Legler DF, et al. (2002). "CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation.". Nat. Immunol. 3 (9): 836–43. doi:10.1038/ni830. PMID 12154360. 
  • Pomerantz JL, Denny EM, Baltimore D (2002). "CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex.". EMBO J. 21 (19): 5184–94. PMID 12356734. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205. 
  • Wang D, Matsumoto R, You Y, et al. (2004). "CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1.". Mol. Cell. Biol. 24 (1): 164–71. PMID 14673152. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Stilo R, Liguoro D, Di Jeso B, et al. (2004). "Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator.". J. Biol. Chem. 279 (33): 34323–31. doi:10.1074/jbc.M402244200. PMID 15184390. 
  • Lee KY, D'Acquisto F, Hayden MS, et al. (2005). "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation.". Science 308 (5718): 114–8. doi:10.1126/science.1107107. PMID 15802604. 
  • Shinohara H, Yasuda T, Aiba Y, et al. (2006). "PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1.". J. Exp. Med. 202 (10): 1423–31. doi:10.1084/jem.20051591. PMID 16301747. 
  • Sommer K, Guo B, Pomerantz JL, et al. (2006). "Phosphorylation of the CARMA1 linker controls NF-kappaB activation.". Immunity 23 (6): 561–74. doi:10.1016/j.immuni.2005.09.014. PMID 16356855. 
  • Matsumoto R, Wang D, Blonska M, et al. (2006). "Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation.". Immunity 23 (6): 575–85. doi:10.1016/j.immuni.2005.10.007. PMID 16356856. 
  • Narayan P, Holt B, Tosti R, Kane LP (2006). "CARMA1 is required for Akt-mediated NF-kappaB activation in T cells.". Mol. Cell. Biol. 26 (6): 2327–36. doi:10.1128/MCB.26.6.2327-2336.2006. PMID 16508008. 
  • Ishiguro K, Avruch J, Landry A, et al. (2006). "Nore1B regulates TCR signaling via Ras and Carma1.". Cell. Signal. 18 (10): 1647–54. doi:10.1016/j.cellsig.2006.01.015. PMID 16520020. 
  • Ishiguro K, Green T, Rapley J, et al. (2006). "Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation.". Mol. Cell. Biol. 26 (14): 5497–508. doi:10.1128/MCB.02469-05. PMID 16809782. 
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