CARD10

From Wikipedia, the free encyclopedia

Caspase recruitment domain family, member 10

Identifiers

CARD10; BIMP1; CARMA3; MGC142219

External IDs

OMIM: 607209 MGI: 2146012 HomoloGene: 8728

Gene ontology
Molecular Function:	• protein binding • receptor signaling complex scaffold activity
Cellular Component:	• intracellular • cytoplasm • CBM complex
Biological Process:	• protein complex assembly • activation of NF-kappaB-inducing kinase • regulation of apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014550 (mRNA)
NP_055365 (protein)

XM_001000894 (mRNA)
XP_001000894 (protein)

Location

Chr 22: 36.22 - 36.25 Mb

Chr 15: 78.6 - 78.63 Mb

Pubmed search

[1]

[2]

Caspase recruitment domain family, member 10, also known as CARD10, is a human gene.^[1]

The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. CARDs induce nuclear factor kappa-B (NFKB; MIM 164011) activity through the IKK (e.g., IKBKB; MIM 603258) complex. CARD9 (MIM 607212), CARD10, CARD11 (MIM 607210), and CARD14 (MIM 607211) interact with BCL10 (MIM 603517) and are involved in NFKB signaling complexes. Except for CARD9, these CARD proteins are members of the membrane-associated guanylate kinase (MAGUK) family.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: CARD10 caspase recruitment domain family, member 10.

[edit] Further reading

Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Wang L, Guo Y, Huang WJ, et al. (2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.
Gaide O, Martinon F, Micheau O, et al. (2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation.". FEBS Lett. 496 (2-3): 121–7. PMID 11356195.
McAllister-Lucas LM, Inohara N, Lucas PC, et al. (2001). "Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction.". J. Biol. Chem. 276 (33): 30589–97. doi:10.1074/jbc.M103824200. PMID 11387339.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Sun L, Deng L, Ea CK, et al. (2004). "The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes.". Mol. Cell 14 (3): 289–301. PMID 15125833.
Stilo R, Liguoro D, Di Jeso B, et al. (2004). "Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator.". J. Biol. Chem. 279 (33): 34323–31. doi:10.1074/jbc.M402244200. PMID 15184390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
McAllister-Lucas LM, Ruland J, Siu K, et al. (2007). "CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells.". Proc. Natl. Acad. Sci. U.S.A. 104 (1): 139–44. doi:10.1073/pnas.0601947103. PMID 17101977.