CAPZB

From Wikipedia, the free encyclopedia

Capping protein (actin filament) muscle Z-line, beta

PDB rendering based on 1izn.

Available structures: 1izn

Identifiers

Symbol(s)

CAPZB; CAPZ; CAPB; CAPPB; MGC104401; MGC129749; MGC129750

External IDs

OMIM: 601572 MGI: 104652 HomoloGene: 3620

Gene ontology
Molecular Function:	• actin binding • peptidyl-dipeptidase A activity
Cellular Component:	• F-actin capping protein complex • membrane
Biological Process:	• proteolysis • cell motility • actin cytoskeleton organization and biogenesis • barbed-end actin filament capping

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004930 (mRNA)
NP_004921 (protein)

NM_001037761 (mRNA)
NP_001032850 (protein)

Location

Chr 1: 19.54 - 19.68 Mb

Chr 4: 138.46 - 138.56 Mb

Pubmed search

[1]

[2]

Capping protein (actin filament) muscle Z-line, beta, also known as CAPZB, is a human gene.^[1]

CAPZB is a member of the F-actin capping protein family. This gene encodes the beta subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments.^[1]

[edit] References

^ ^a ^b Entrez Gene: CAPZB capping protein (actin filament) muscle Z-line, beta.

[edit] Further reading

Barron-Casella EA, Torres MA, Scherer SW, et al. (1995). "Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families.". J. Biol. Chem. 270 (37): 21472–9. PMID 7665558.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.". Proteomics 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Wells CD, Fawcett JP, Traweger A, et al. (2006). "A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells.". Cell 125 (3): 535–48. doi:10.1016/j.cell.2006.02.045. PMID 16678097.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.