CAPZA2

From Wikipedia, the free encyclopedia

Capping protein (actin filament) muscle Z-line, alpha 2

Identifiers

CAPZA2; CAPZ; CAPPA2

External IDs

OMIM: 601571 MGI: 106222 HomoloGene: 55956

Gene ontology
Molecular Function:	• actin binding
Cellular Component:	• F-actin capping protein complex
Biological Process:	• protein complex assembly • cell motility • actin cytoskeleton organization and biogenesis • barbed-end actin filament capping

Orthologs

Human

Mouse

Refseq

NM_006136 (mRNA)
NP_006127 (protein)

NM_007604 (mRNA)
NP_031630 (protein)

Location

Chr 7: 116.29 - 116.35 Mb

Chr 6: 17.59 - 17.62 Mb

Pubmed search

[1]

[2]

Capping protein (actin filament) muscle Z-line, alpha 2, also known as CAPZA2, is a human gene.^[1]

The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end.^[1]

[edit] References

^ ^a ^b Entrez Gene: CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2.

[edit] Further reading

Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317-20. PMID 1602151.
Barron-Casella EA, Torres MA, Scherer SW, et al. (1995). "Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families.". J. Biol. Chem. 270 (37): 21472-9. PMID 7665558.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Hart MC, Korshunova YO, Cooper JA (1997). "Vertebrates have conserved capping protein alpha isoforms with specific expression patterns.". Cell Motil. Cytoskeleton 38 (2): 120-32. doi:10.1002/(SICI)1097-0169(1997)38:2<120::AID-CM2>3.0.CO;2-B. PMID 9331217.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Miyagawa Y, Tanaka H, Iguchi N, et al. (2003). "Molecular cloning and characterization of the human orthologue of male germ cell-specific actin capping protein alpha3 (cpalpha3).". Mol. Hum. Reprod. 8 (6): 531-9. PMID 12029070.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767-72. doi:10.1126/science.1083423. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.