CAPZA1

From Wikipedia, the free encyclopedia

Capping protein (actin filament) muscle Z-line, alpha 1

PDB rendering based on 1izn.

Available structures: 1izn

Identifiers

Symbol(s)

CAPZA1; CAPPA1; CAPZ; CAZ1

External IDs

OMIM: 601580 MGI: 106227 HomoloGene: 24376

Gene ontology
Molecular Function:	• actin binding
Cellular Component:	• F-actin capping protein complex
Biological Process:	• protein complex assembly • cell motility • actin cytoskeleton organization and biogenesis • barbed-end actin filament capping

Orthologs

Human

Mouse

Refseq

NM_006135 (mRNA)
NP_006126 (protein)

NM_009797 (mRNA)
NP_033927 (protein)

Location

Chr 1: 112.96 - 113.02 Mb

Chr 3: 104.95 - 104.97 Mb

Pubmed search

[1]

[2]

Capping protein (actin filament) muscle Z-line, alpha 1, also known as CAPZA1, is a human gene.^[1]

CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments.^[1]

[edit] References

^ ^a ^b Entrez Gene: CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1.

[edit] Further reading

Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. PMID 1602151.
Barron-Casella EA, Torres MA, Scherer SW, et al. (1995). "Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families.". J. Biol. Chem. 270 (37): 21472–9. PMID 7665558.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Maun NA, Speicher DW, DiNubile MJ, Southwick FS (1996). "Purification and properties of a Ca(2+)-independent barbed-end actin filament capping protein, CapZ, from human polymorphonuclear leukocytes.". Biochemistry 35 (11): 3518–24. doi:10.1021/bi952470p. PMID 8639502.
Hart MC, Korshunova YO, Cooper JA (1997). "Mapping of the mouse actin capping protein alpha subunit genes and pseudogenes.". Genomics 39 (3): 264–70. doi:10.1006/geno.1996.4506. PMID 9119363.
Hart MC, Korshunova YO, Cooper JA (1997). "Vertebrates have conserved capping protein alpha isoforms with specific expression patterns.". Cell Motil. Cytoskeleton 38 (2): 120–32. doi:10.1002/(SICI)1097-0169(1997)38:2<120::AID-CM2>3.0.CO;2-B. PMID 9331217.
Kuhlman PA, Fowler VM (1997). "Purification and characterization of an alpha 1 beta 2 isoform of CapZ from human erythrocytes: cytosolic location and inability to bind to Mg2+ ghosts suggest that erythrocyte actin filaments are capped by adducin.". Biochemistry 36 (44): 13461–72. doi:10.1021/bi970601b. PMID 9354614.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Osterloh D, Ivanenkov VV, Gerke V (1999). "Hydrophobic residues in the C-terminal region of S100A1 are essential for target protein binding but not for dimerization.". Cell Calcium 24 (2): 137–51. PMID 9803314.
Inman KG, Yang R, Rustandi RR, et al. (2003). "Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12.". J. Mol. Biol. 324 (5): 1003–14. PMID 12470955.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
McClintock KA, Shaw GS (2003). "A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex.". J. Biol. Chem. 278 (8): 6251–7. doi:10.1074/jbc.M210622200. PMID 12480931.
Taoka M, Ichimura T, Wakamiya-Tsuruta A, et al. (2003). "V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein.". J. Biol. Chem. 278 (8): 5864–70. doi:10.1074/jbc.M211509200. PMID 12488317.
Hutchings NJ, Clarkson N, Chalkley R, et al. (2003). "Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85.". J. Biol. Chem. 278 (25): 22396–403. doi:10.1074/jbc.M302540200. PMID 12690097.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.". Proteomics 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Canton DA, Olsten ME, Niederstrasser H, et al. (2007). "The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein.". J. Biol. Chem. 281 (47): 36347–59. doi:10.1074/jbc.M607595200. PMID 16987810.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.