CAPNS1

From Wikipedia, the free encyclopedia


Calpain, small subunit 1
PDB rendering based on 1aj5.
Available structures: 1aj5, 1alv, 1alw, 1df0, 1dvi, 1kfu, 1kfx, 1np8, 1nx0, 1nx1, 1nx2, 1nx3, 1u5i
Identifiers
Symbol(s) CAPNS1; CANP; 30K; CALPAIN4; CANPS; CAPN4; CDPS
External IDs OMIM: 114170 MGI: 88266 HomoloGene: 1327
Orthologs
Human Mouse
Entrez 826 12336
Ensembl ENSG00000126247 ENSMUSG00000001794
Uniprot P04632 O88456
Refseq NM_001003962 (mRNA)
NP_001003962 (protein)		 XM_001000249 (mRNA)
XP_001000249 (protein)
Location Chr 19: 41.32 - 41.33 Mb Chr 7: 29.9 - 29.9 Mb
Pubmed search [1] [2]

Calpain, small subunit 1, also known as CAPNS1, is a human gene.[1]

Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: CAPNS1 calpain, small subunit 1.

[edit] Further reading

  • Suzuki K, Sorimachi H, Yoshizawa T, et al. (1996). "Calpain: novel family members, activation, and physiologic function.". Biol. Chem. Hoppe-Seyler 376 (9): 523–9. PMID 8561910. 
  • Tidball JG, Spencer MJ (2000). "Calpains and muscular dystrophies.". Int. J. Biochem. Cell Biol. 32 (1): 1–5. PMID 10661889. 
  • Huang Y, Wang KK (2001). "The calpain family and human disease.". Trends in molecular medicine 7 (8): 355–62. PMID 11516996. 
  • Reverter D, Sorimachi H, Bode W (2001). "The structure of calcium-free human m-calpain: implications for calcium activation and function.". Trends Cardiovasc. Med. 11 (6): 222–9. PMID 11673052. 
  • Banik NL, DeVries GH, Neuberger T, et al. (1991). "Calcium-activated neutral proteinase (CANP; calpain) activity in Schwann cells: immunofluorescence localization and compartmentation of mu- and mCANP.". J. Neurosci. Res. 29 (3): 346–54. doi:10.1002/jnr.490290310. PMID 1656060. 
  • Ohno S, Minoshima S, Kudoh J, et al. (1990). "Four genes for the calpain family locate on four distinct human chromosomes.". Cytogenet. Cell Genet. 53 (4): 225–9. PMID 2209092. 
  • Ohno S, Emori Y, Suzuki K (1986). "Nucleotide sequence of a cDNA coding for the small subunit of human calcium-dependent protease.". Nucleic Acids Res. 14 (13): 5559. PMID 3016651. 
  • Miyake S, Emori Y, Suzuki K (1987). "Gene organization of the small subunit of human calcium-activated neutral protease.". Nucleic Acids Res. 14 (22): 8805–17. PMID 3024120. 
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Zhang W, Lane RD, Mellgren RL (1996). "The major calpain isozymes are long-lived proteins. Design of an antisense strategy for calpain depletion in cultured cells.". J. Biol. Chem. 271 (31): 18825–30. PMID 8702541. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174. 
  • Noguchi M, Sarin A, Aman MJ, et al. (1997). "Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain.". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11534–9. PMID 9326644. 
  • Strobl S, Fernandez-Catalan C, Braun M, et al. (2000). "The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.". Proc. Natl. Acad. Sci. U.S.A. 97 (2): 588–92. PMID 10639123. 
  • Masumoto H, Nakagawa K, Irie S, et al. (2000). "Crystallization and preliminary X-ray analysis of recombinant full-length human m-calpain.". Acta Crystallogr. D Biol. Crystallogr. 56 (Pt 1): 73–5. PMID 10666632. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800. 
  • Reverter D, Strobl S, Fernandez-Catalan C, et al. (2002). "Structural basis for possible calcium-induced activation mechanisms of calpains.". Biol. Chem. 382 (5): 753–66. PMID 11517928. 
 This article on a gene on chromosome 19 is a stub. You can help Wikipedia by expanding it.