CAPN5

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Calpain 5
Identifiers
Symbol(s) CAPN5; FLJ46245; HTRA3; nCL-3
External IDs OMIM: 602537 MGI: 1100859 HomoloGene: 31212
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 726 12337
Ensembl ENSG00000149260 ENSMUSG00000035547
Uniprot O15484 Q3TDS7
Refseq NM_004055 (mRNA)
NP_004046 (protein)		 NM_007602 (mRNA)
NP_031628 (protein)
Location Chr 11: 76.46 - 76.51 Mb Chr 7: 98 - 98.05 Mb
Pubmed search [1] [2]

Calpain 5, also known as CAPN5, is a human gene.[1]

Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.[1]

[edit] References

  1. ^ a b Entrez Gene: CAPN5 calpain 5.

[edit] Further reading

  • Vanderklish PW, Bahr BA (2001). "The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states.". International journal of experimental pathology 81 (5): 323–39. PMID 11168679. 
  • Sato K, Kawashima S (2002). "Calpain function in the modulation of signal transduction molecules.". Biol. Chem. 382 (5): 743–51. PMID 11517927. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Dear N, Matena K, Vingron M, Boehm T (1997). "A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution.". Genomics 45 (1): 175–84. doi:10.1006/geno.1997.4870. PMID 9339374. 
  • Mugita N, Kimura Y, Ogawa M, et al. (1997). "Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene.". Biochem. Biophys. Res. Commun. 239 (3): 845–50. doi:10.1006/bbrc.1997.7571. PMID 9367857. 
  • Matena K, Boehm T, Dear N (1998). "Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily.". Genomics 48 (1): 117–20. PMID 9503024. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Waghray A, Wang DS, McKinsey D, et al. (2004). "Molecular cloning and characterization of rat and human calpain-5.". Biochem. Biophys. Res. Commun. 324 (1): 46–51. doi:10.1016/j.bbrc.2004.09.012. PMID 15464980. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • González A, Sáez ME, Aragón MJ, et al. (2006). "Specific haplotypes of the CALPAIN-5 gene are associated with polycystic ovary syndrome.". Hum. Reprod. 21 (4): 943–51. doi:10.1093/humrep/dei443. PMID 16396936. 
  • Sáez ME, Martínez-Larrad MT, Ramírez-Lorca R, et al. (2007). "Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels.". BMC Med. Genet. 8: 1. doi:10.1186/1471-2350-8-1. PMID 17227582. 
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