CAND1

From Wikipedia, the free encyclopedia

Cullin-associated and neddylation-dissociated 1

PDB rendering based on 1u6g.

Available structures: 1u6g

Identifiers

Symbol(s)

CAND1; DKFZp434M1414; FLJ10114; FLJ10929; FLJ38691; FLJ90441; KIAA0829; TIP120; TIP120A

External IDs

OMIM: 607727 MGI: 1261820 HomoloGene: 10202

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• ubiquitin ligase complex • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • protein ubiquitination • cell differentiation • negative regulation of enzyme activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018448 (mRNA)
NP_060918 (protein)

XM_125901 (mRNA)
XP_125901 (protein)

Location

Chr 12: 65.95 - 65.99 Mb

Chr 10: 118.61 - 118.64 Mb

Pubmed search

[1]

[2]

Cullin-associated and neddylation-dissociated 1, also known as CAND1, is a human gene.^[1]

[edit] References

^ Entrez Gene: CAND1 cullin-associated and neddylation-dissociated 1.

[edit] Further reading

Yogosawa S, Makino Y, Yoshida T, et al. (1997). "Molecular cloning of a novel 120-kDa TBP-interacting protein.". Biochem. Biophys. Res. Commun. 229 (2): 612–7. PMID 8954946.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355–64. PMID 10048485.
Yogosawa S, Kayukawa K, Kawata T, et al. (2000). "Induced expression, localization, and chromosome mapping of a gene for the TBP-interacting protein 120A.". Biochem. Biophys. Res. Commun. 266 (1): 123–8. doi:10.1006/bbrc.1999.1773. PMID 10581176.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Liu J, Furukawa M, Matsumoto T, Xiong Y (2003). "NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.". Mol. Cell 10 (6): 1511–8. PMID 12504025.
Zheng J, Yang X, Harrell JM, et al. (2003). "CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.". Mol. Cell 10 (6): 1519–26. PMID 12504026.
Min KW, Hwang JW, Lee JS, et al. (2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity.". J. Biol. Chem. 278 (18): 15905–10. doi:10.1074/jbc.M213070200. PMID 12609982.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Feng S, Shen Y, Sullivan JA, et al. (2004). "Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation.". Plant Cell 16 (7): 1870–82. doi:10.1105/tpc.021949. PMID 15208391.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Goldenberg SJ, Cascio TC, Shumway SD, et al. (2004). "Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases.". Cell 119 (4): 517–28. doi:10.1016/j.cell.2004.10.019. PMID 15537541.
Min KW, Kwon MJ, Park HS, et al. (2006). "CAND1 enhances deneddylation of CUL1 by COP9 signalosome.". Biochem. Biophys. Res. Commun. 334 (3): 867–74. doi:10.1016/j.bbrc.2005.06.188. PMID 16036220.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.