CAMLG

From Wikipedia, the free encyclopedia

Calcium modulating ligand

Identifiers

CAMLG; CAML; MGC163197

External IDs

OMIM: 601118 MGI: 104728 HomoloGene: 1323

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• receptor recycling • defense response • epidermal growth factor receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001745 (mRNA)
NP_001736 (protein)

NM_007596 (mRNA)
NP_031622 (protein)

Location

Chr 5: 134.1 - 134.12 Mb

Chr 13: 55.63 - 55.64 Mb

Pubmed search

[1]

[2]

Calcium modulating ligand, also known as CAMLG, is a human gene.^[1]

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.^[1]

[edit] References

^ ^a ^b Entrez Gene: CAMLG calcium modulating ligand.

[edit] See also

Calcium-modulating cyclophilin ligand

[edit] Further reading

Bram RJ, Crabtree GR (1994). "Calcium signalling in T cells stimulated by a cyclophilin B-binding protein.". Nature 371 (6495): 355-8. doi:10.1038/371355a0. PMID 7522304.
Bram RJ, Valentine V, Shapiro DN, et al. (1997). "The gene for calcium-modulating cyclophilin ligand (CAMLG) is located on human chromosome 5q23 and a syntenic region of mouse chromosome 13.". Genomics 31 (2): 257-60. doi:10.1006/geno.1996.0044. PMID 8824814.
von Bülow GU, Bram RJ (1997). "NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily.". Science 278 (5335): 138-41. PMID 9311921.
Holloway MP, Bram RJ (1998). "Co-localization of calcium-modulating cyclophilin ligand with intracellular calcium pools.". J. Biol. Chem. 273 (26): 16346-50. PMID 9632697.
Tovey SC, Bootman MD, Lipp P, et al. (2000). "Calcium-modulating cyclophilin ligand desensitizes hormone-evoked calcium release.". Biochem. Biophys. Res. Commun. 276 (1): 97-100. doi:10.1006/bbrc.2000.3442. PMID 11006089.
Larramendy ML, Niini T, Elonen E, et al. (2003). "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis.". Haematologica 87 (6): 569-77. PMID 12031912.
Feng P, Park J, Lee BS, et al. (2002). "Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis.". J. Virol. 76 (22): 11491-504. PMID 12388711.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Tran DD, Russell HR, Sutor SL, et al. (2003). "CAML is required for efficient EGF receptor recycling.". Dev. Cell 5 (2): 245-56. PMID 12919676.
Kumar R, Lutz W, Frank E, Im HJ (2004). "Immediate early gene X-1 interacts with proteins that modulate apoptosis.". Biochem. Biophys. Res. Commun. 323 (4): 1293-8. doi:10.1016/j.bbrc.2004.09.006. PMID 15451437.
Guo S, Lopez-Ilasaca M, Dzau VJ (2005). "Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation.". J. Biol. Chem. 280 (13): 12536-41. doi:10.1074/jbc.M500296200. PMID 15668245.
Nagano J, Kitamura K, Hujer KM, et al. (2006). "Fibrocystin interacts with CAML, a protein involved in Ca2+ signaling.". Biochem. Biophys. Res. Commun. 338 (2): 880-9. doi:10.1016/j.bbrc.2005.10.022. PMID 16243292.