CAMKK2

From Wikipedia, the free encyclopedia

Calcium/calmodulin-dependent protein kinase kinase 2, beta

Identifiers

CAMKK2; CAMKK; CAMKKB; KIAA0787; MGC15254

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • calmodulin-dependent protein kinase activity • protein-tyrosine kinase activity • calcium ion binding • calmodulin binding • ATP binding • transferase activity
Cellular Component:	• intracellular
Biological Process:	• MAPKKK cascade • calcium-mediated signaling • regulation of protein kinase activity • positive regulation of transcription • protein amino acid autophosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006549 (mRNA)
NP_006540 (protein)

NM_145358 (mRNA)
NP_663333 (protein)

Location

Chr 12: 120.16 - 120.22 Mb

Chr 5: 122.99 - 123.04 Mb

Pubmed search

[1]

[2]

Calcium/calmodulin-dependent protein kinase kinase 2, beta, also known as CAMKK2, is a human gene.^[1]

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Seven transcript variants encoding six distinct isoforms have been identified for this gene. Additional splice variants have been described but their full-length nature has not been determined. The identified isoforms exhibit a distinct ability to undergo autophosphorylation and to phosphorylate the downstream kinases.^[1]

[edit] References

^ ^a ^b Entrez Gene: CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Hsu LS, Tsou AP, Chi CW, et al. (1998). "Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase.". J. Biomed. Sci. 5 (2): 141–9. PMID 9662074.
Anderson KA, Means RL, Huang QH, et al. (1998). "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.". J. Biol. Chem. 273 (48): 31880–9. PMID 9822657.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. PMID 9872452.
Hsu LS, Chen GD, Lee LS, et al. (2001). "Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity.". J. Biol. Chem. 276 (33): 31113–23. doi:10.1074/jbc.M011720200. PMID 11395482.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Imai S, Okayama N, Shimizu M, Itoh M (2003). "Increased intracellular calcium activates serum and glucocorticoid-inducible kinase 1 (SGK1) through a calmodulin-calcium calmodulin dependent kinase kinase pathway in Chinese hamster ovary cells.". Life Sci. 72 (20): 2199–209. PMID 12628440.
Ishikawa Y, Tokumitsu H, Inuzuka H, et al. (2003). "Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells.". FEBS Lett. 550 (1-3): 57–63. PMID 12935886.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hawley SA, Pan DA, Mustard KJ, et al. (2005). "Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.". Cell Metab. 2 (1): 9–19. doi:10.1016/j.cmet.2005.05.009. PMID 16054095.
Woods A, Dickerson K, Heath R, et al. (2005). "Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.". Cell Metab. 2 (1): 21–33. doi:10.1016/j.cmet.2005.06.005. PMID 16054096.
Novak G, Seeman P, Tallerico T (2006). "Increased expression of calcium/calmodulin-dependent protein kinase IIbeta in frontal cortex in schizophrenia and depression.". Synapse 59 (1): 61–8. doi:10.1002/syn.20211. PMID 16247765.
Stahmann N, Woods A, Carling D, Heller R (2006). "Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta.". Mol. Cell. Biol. 26 (16): 5933–45. doi:10.1128/MCB.00383-06. PMID 16880506.
Erhardt A, Lucae S, Unschuld PG, et al. (2007). "Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders.". Journal of affective disorders 101 (1-3): 159–68. doi:10.1016/j.jad.2006.11.016. PMID 17197037.