CAMKK1
From Wikipedia, the free encyclopedia
Calcium/calmodulin-dependent protein kinase kinase 1, alpha
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Identifiers | ||||||||||||||
Symbol(s) | CAMKK1; CAMKKA; DKFZp761M0423; MGC34095 | |||||||||||||
External IDs | MGI: 1891766 HomoloGene: 10327 | |||||||||||||
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Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 84254 | 55984 | ||||||||||||
Ensembl | ENSG00000004660 | ENSMUSG00000020785 | ||||||||||||
Uniprot | Q8N5S9 | Q5SRU3 | ||||||||||||
Refseq | NM_032294 (mRNA) NP_115670 (protein) |
NM_018883 (mRNA) NP_061371 (protein) |
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Location | Chr 17: 3.71 - 3.74 Mb | Chr 11: 72.84 - 72.86 Mb | ||||||||||||
Pubmed search | [1] | [2] |
Calcium/calmodulin-dependent protein kinase kinase 1, alpha, also known as CAMKK1, is a human gene.[1]
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene.[1]
[edit] References
[edit] Further reading
- Selbert MA, Anderson KA, Huang QH, et al. (1995). "Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation.". J. Biol. Chem. 270 (29): 17616-21. PMID 7615569.
- Tokumitsu H, Enslen H, Soderling TR (1995). "Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase.". J. Biol. Chem. 270 (33): 19320-4. PMID 7642608.
- Tokumitsu H, Soderling TR (1996). "Requirements for calcium and calmodulin in the calmodulin kinase activation cascade.". J. Biol. Chem. 271 (10): 5617-22. PMID 8621423.
- Matsushita M, Nairn AC (1998). "Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase.". J. Biol. Chem. 273 (34): 21473-81. PMID 9705275.
- Matsushita M, Nairn AC (1999). "Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase.". J. Biol. Chem. 274 (15): 10086-93. PMID 10187789.
- Lawson ND, Zain M, Zibello T, et al. (1999). "Modulation of a calcium/calmodulin-dependent protein kinase cascade by retinoic acid during neutrophil maturation.". Exp. Hematol. 27 (11): 1682-90. PMID 10560916.
- Okuno S, Kitani T, Matsuzaki H, et al. (2000). "Studies on the phosphorylation of protein kinase B by Ca(2+)/calmodulin-dependent protein kinases.". J. Biochem. 127 (6): 965-70. PMID 10833263.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi: . PMID 11230166.
- Okuno S, Kitani T, Fujisawa H (2002). "Regulation of Ca(2+)/calmodulin-dependent protein kinase kinase alpha by cAMP-dependent protein kinase: I. Biochemical analysis.". J. Biochem. 130 (4): 503-13. PMID 11574070.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi: . PMID 12477932.
- Imai S, Okayama N, Shimizu M, Itoh M (2003). "Increased intracellular calcium activates serum and glucocorticoid-inducible kinase 1 (SGK1) through a calmodulin-calcium calmodulin dependent kinase kinase pathway in Chinese hamster ovary cells.". Life Sci. 72 (20): 2199-209. PMID 12628440.
- Ishikawa Y, Tokumitsu H, Inuzuka H, et al. (2003). "Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells.". FEBS Lett. 550 (1-3): 57-63. PMID 12935886.
- Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436-50. doi: . PMID 15324660.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi: . PMID 15489334.