CAMK4

From Wikipedia, the free encyclopedia

Calcium/calmodulin-dependent protein kinase IV

Identifiers

CAMK4; CaMK-GR; MGC36771

External IDs

OMIM: 114080 MGI: 88258 HomoloGene: 74407

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • calmodulin-dependent protein kinase activity • calcium ion binding • calmodulin binding • ATP binding • transcription activator activity • transferase activity
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• protein amino acid phosphorylation • nucleocytoplasmic transport • signal transduction • nerve-nerve synaptic transmission

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001744 (mRNA)
NP_001735 (protein)

NM_009793 (mRNA)
NP_033923 (protein)

Location

Chr 5: 110.59 - 110.86 Mb

Chr 18: 33.08 - 33.31 Mb

Pubmed search

[1]

[2]

Calcium/calmodulin-dependent protein kinase IV, also known as CAMK4, is a human gene.

The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.^[1]

[edit] References

^ Entrez Gene: CAMK4 calcium/calmodulin-dependent protein kinase IV.

[edit] Further reading

Bredt DS, Ferris CD, Snyder SH (1992). "Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.". J. Biol. Chem. 267 (16): 10976–81. PMID 1375933.
Jensen KF, Ohmstede CA, Fisher RS, Sahyoun N (1991). "Nuclear and axonal localization of Ca2+/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex.". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2850–3. PMID 2011593.
Sikela JM, Law ML, Kao FT, et al. (1989). "Chromosomal localization of the human gene for brain Ca2+/calmodulin-dependent protein kinase type IV.". Genomics 4 (1): 21–7. PMID 2536634.
Selbert MA, Anderson KA, Huang QH, et al. (1995). "Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation.". J. Biol. Chem. 270 (29): 17616–21. PMID 7615569.
Kitani T, Okuno S, Fujisawa H (1994). "cDNA cloning and expression of human calmodulin-dependent protein kinase IV.". J. Biochem. 115 (4): 637–40. PMID 8089075.
Mosialos G, Hanissian SH, Jawahar S, et al. (1994). "A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1.". J. Virol. 68 (3): 1697–705. PMID 8107230.
Bland MM, Monroe RS, Ohmstede CA (1994). "The cDNA sequence and characterization of the Ca2+/calmodulin-dependent protein kinase-Gr from human brain and thymus.". Gene 142 (2): 191–7. PMID 8194751.
Tokumitsu H, Soderling TR (1996). "Requirements for calcium and calmodulin in the calmodulin kinase activation cascade.". J. Biol. Chem. 271 (10): 5617–22. PMID 8621423.
Chatila T, Anderson KA, Ho N, Means AR (1996). "A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR.". J. Biol. Chem. 271 (35): 21542–8. PMID 8702940.
Melander Gradin H, Marklund U, Larsson N, et al. (1997). "Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18.". Mol. Cell. Biol. 17 (6): 3459–67. PMID 9154845.
Matsushita M, Nairn AC (1998). "Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase.". J. Biol. Chem. 273 (34): 21473–81. PMID 9705275.
Anderson KA, Means RL, Huang QH, et al. (1998). "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.". J. Biol. Chem. 273 (48): 31880–9. PMID 9822657.
Hayashi Y, Nishio M, Naito Y, et al. (1999). "Regulation of neuronal nitric-oxide synthase by calmodulin kinases.". J. Biol. Chem. 274 (29): 20597–602. PMID 10400690.
Blaeser F, Ho N, Prywes R, Chatila TA (2000). "Ca(2+)-dependent gene expression mediated by MEF2 transcription factors.". J. Biol. Chem. 275 (1): 197–209. PMID 10617605.
Moreno CS, Park S, Nelson K, et al. (2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A.". J. Biol. Chem. 275 (8): 5257–63. PMID 10681496.
Komeima K, Hayashi Y, Naito Y, Watanabe Y (2000). "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells.". J. Biol. Chem. 275 (36): 28139–43. doi:10.1074/jbc.M003198200. PMID 10874031.
Wu JY, Ribar TJ, Cummings DE, et al. (2000). "Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4.". Nat. Genet. 25 (4): 448–52. doi:10.1038/78153. PMID 10932193.
Jang MK, Goo YH, Sohn YC, et al. (2001). "Ca2+/calmodulin-dependent protein kinase IV stimulates nuclear factor-kappa B transactivation via phosphorylation of the p65 subunit.". J. Biol. Chem. 276 (23): 20005–10. doi:10.1074/jbc.M010211200. PMID 11274168.
Hsu LS, Chen GD, Lee LS, et al. (2001). "Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity.". J. Biol. Chem. 276 (33): 31113–23. doi:10.1074/jbc.M011720200. PMID 11395482.
Zhao X, Ito A, Kane CD, et al. (2001). "The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking.". J. Biol. Chem. 276 (37): 35042–8. doi:10.1074/jbc.M105086200. PMID 11470791.