Calsequestrin

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Calsequestrin monomer showing the three repeating calsequestrin domains
calsequestrin 1 (fast-twitch, skeletal muscle)
Identifiers
Symbol	CASQ1
Alt. Symbols	CASQ
Entrez	844
HUGO	1512
OMIM	114250
PDB	1A8Y
RefSeq	NM_001231
UniProt	P31415
Other data
Locus	Chr. 1 q21

calsequestrin 2 (cardiac muscle)
Identifiers
Symbol	CASQ2
Entrez	845
HUGO	1513
OMIM	114251
RefSeq	NM_001232
UniProt	O14958
Other data
Locus	Chr. 1 p13.3-p11

Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. The protein helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. It also helps sarcoplasmic reticulum store an amazing amount of calcium ions.

[edit] External links

MeSH Calsequestrin

[edit] References

Wang S, Trumble WR, Liao H, Wesson CR, Dunker AK, Kang CH (1998). "Crystal structure of calsequestrin from rabbit skeletal muscle sarcoplasmic reticulum". Nat. Struct. Biol. 5 (6): 476–83. PMID 9628486.

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v • d • e Cell signaling: calcium signaling

Second messengers	IP3 - NAADP - cADPR

Intracellular calcium store gates	IP3 receptor - Ryanodine receptor - putative NAADP receptor

Calcium pumps and exchangers	SERCA - Na/Ca antiport - Ca/H antiport

calcium-binding protein domains	EF hand domain - C2 domain

Calcium-based molecular switches, and kinases	Troponin C - CaM - CaM kinases - PKC - NCS

Intracellular calcium chelators (calcium buffers) and calcium sensors	Calbindin - S100 - pervalbumin - Calretinin - Calsequestrin - Sarcalumenin - Phospholamban - Synaptotagmins

Calcium-dependent proteases	Calpain

Calcium-dependent cytoskeleton remodeling proteins	Gelsolin

Cell membrane calcium channels	VDCC - TRP - NMDA receptor - AMPA receptor - 5-HT3 receptor - P2X Receptor

Calcium-regulated chaperones	calreticulin - calnexin

Calcium-based adhesion molecules	Cadherin

Calcium homeostasis	Parathyroid hormone - Calcitonin - calcium receptor - vitamin D

v • d • e Carrier protein: calcium-binding proteins

Intracellular calcium-sensing proteins	Calmodulin - Calnexin - Calreticulin - Gelsolin - neuronal (Hippocalcin, Neurocalcin, Recoverin)

Other	Annexin (A1, A2, A5) - Vitamin D-dependent calcium-binding protein/Calbindin - Calexcitin - Calsequestrin - Fibulin - Matrix gla protein - Osteocalcin - Osteonectin - S-100 - Synaptotagmin - Troponin C