Calicheamicin
From Wikipedia, the free encyclopedia
Calicheamicin is an antibiotic derived from organism Micromonospora echinospora. It was isolated originally from a rock collected in Waco, Texas by a hiking Scripps Institute chemist.
It is highly toxic but has found pharmacological use as a conjugate in antibody cancer therapeutics (e.g. Gemtuzumab).
[edit] References
- http://www.scripps.edu/newsandviews/e_20010226/nicolaou3.html
- J Antibiot (Tokyo). 1989 Jul;42(7):1070-87.