Calcium pump

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There is a very large transmembrane electrochemical gradient of Ca2+ driving the entry of the ion into cells, yet it is very important for cells to maintain low concentrations of Ca2+ for proper cell signalling; thus it is necessary for the cell to employ ion pumps to remove the Ca2+.[1]

The PMCA and the sodium calcium exchanger (NCX) are together the main regulators of intracellular Ca2+ concentrations.[2]


[edit] References

  1. ^ Carafoli, E (1991). "Calcium pump of the plasma membrane". Physiological Reviews 71 (1): 129-153. PMID 1986387. 
  2. ^ Strehler, EE; Zacharias DA (2001). "Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps". Physiological Reviews 81 (1): 21-50. American Physiological Society. PMID 11152753. 
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