Calcium-induced calcium release

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Calcium-induced calcium release (CICR) is a mechanism of calcium release from muscle sarcoplasmic reticulum that was proposed in the 1970s[1]. Originally proposed for skeletal muscle, subsequent research has revealed that it is actually the predominant mechanism in cardiac muscle.

Contents

[edit] CICR in Excitation-Contraction (EC) Coupling

The mechanism that couples excitation - an action potential in the plasma membrane of the muscle cell - and contraction of heart muscle is an increase in the cell's cystolic calcium concentration. This calcium combines with the regulator protein troponin, initiating cross-bridge formation between actin and myosin.

[edit] The Paradox of Regenerative Release

[edit] Termination of CICR

[edit] References

  1. ^ Endo M. (1977). "Calcium release from the sarcoplasmic reticulum.". Physiol Rev 57 (1): 71–108. PMID 13441. 
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