Calcium-binding protein

From Wikipedia, the free encyclopedia

Calcium-binding proteins are proteins that participate in calcium cell signalling pathways by binding to Ca²⁺.

The most ubiquitous Ca²⁺-sensing protein, found in all eukaryotic organisms including yeasts, is calmodulin.

Intracellular storage and release of Ca²⁺ from the sarcoplasmic reticulum is associated with the high-capacity, low-affinity calcium-binding protein, calsequestrin.^[1]

With their role in signal transduction, calcium-binding proteins contribute to all aspects of the cell's functioning, from homeostasis to learning and memory.

For example, the neuron-specific calexcitin has been found to have an excitatory effect on neurons, and interacts with proteins that control the firing state of neurons, such as the the voltage-dependent potassium channel.^[2]

[edit] See also

• Vitamin D-dependent calcium-binding protein
• Wikipedia:MeSH_D12.776#MeSH_D12.776.157.125_---_calcium-binding_proteins

[edit] References

1. ^ Siegel, George (Ed.). Basic neurochemistry : molecular, cellular and medical aspects. Lippincott Williams and Wilkins / 1999 ISBN 0-397-51820-X
2. ^ Nelson T, Cavallaro S, Yi C, McPhie D, Schreurs B, Gusev P, Favit A, Zohar O, Kim J, Beushausen S, Ascoli G, Olds J, Neve R, Alkon D (1996). "Calexcitin: a signaling protein that binds calcium and GTP, inhibits potassium channels, and enhances membrane excitability". Proc Natl Acad Sci U S A 93 (24): 13808–13. doi:10.1073/pnas.93.24.13808. PMID 8943017. 

[edit] External links

• MeSH Calcium-Binding+Proteins

v • d • e Proteins: carrier proteins Hormone Follistatin - Growth hormone binding protein - Insulin-like growth factor binding protein - Neurophysins (Neurophysin I, II) Sex hormone binding globulin/Androgen binding protein - Transcortin - Thyroxine-binding globulin - Transthyretin Metal/element calcium (Calcium-binding protein, Calmodulin-binding proteins) - copper (Ceruloplasmin) - iron (Iron-binding proteins, Transferrin receptor) Vitamin Retinol binding protein (4) - Transcobalamin Other Acyl carrier protein - Adaptor protein - Cholesterylester transfer protein - F-box protein - GTP-binding protein - Latent TGF-beta binding protein - Light-harvesting complex - Membrane transport protein

v • d • e Carrier protein: calcium-binding proteins Intracellular calcium-sensing proteins Calmodulin - Calnexin - Calreticulin - Gelsolin - neuronal (Hippocalcin, Neurocalcin, Recoverin) Other Annexin (A1, A2, A5) - Vitamin D-dependent calcium-binding protein/Calbindin - Calexcitin - Calsequestrin - Fibulin - Matrix gla protein - Osteocalcin - Osteonectin - S-100 - Synaptotagmin - Troponin C