CALML5

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Calmodulin-like 5
PDB rendering based on 2b1u.
Available structures: 2b1u
Identifiers
Symbol(s) CALML5; CLSP
External IDs OMIM: 605183 MGI: 1931464 HomoloGene: 49485
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 51806 80796
Ensembl ENSG00000178372 ENSMUSG00000033765
Uniprot Q9NZT1 Q6WEH7
Refseq NM_017422 (mRNA)
NP_059118 (protein)		 NM_020036 (mRNA)
NP_064420 (protein)
Location Chr 10: 5.53 - 5.53 Mb Chr 13: 3.84 - 3.84 Mb
Pubmed search [1] [2]

Calmodulin-like 5, also known as CALML5, is a human gene.[1]

This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.[1]

[edit] References

  1. ^ a b Entrez Gene: CALML5 calmodulin-like 5.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Méhul B, Bernard D, Simonetti L, et al. (2000). "Identification and cloning of a new calmodulin-like protein from human epidermis.". J. Biol. Chem. 275 (17): 12841–7. PMID 10777582. 
  • Méhul B, Bernard D, Schmidt R (2001). "Calmodulin-like skin protein: a new marker of keratinocyte differentiation.". J. Invest. Dermatol. 116 (6): 905–9. doi:10.1046/j.0022-202x.2001.01376.x. PMID 11407979. 
  • Durussel I, Méhul B, Bernard D, et al. (2002). "Cation- and peptide-binding properties of human calmodulin-like skin protein.". Biochemistry 41 (17): 5439–48. PMID 11969404. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Méhul B, Bernard D, Brouard M, et al. (2006). "Influence of calcium on the proteolytic degradation of the calmodulin-like skin protein (calmodulin-like protein 5) in psoriatic epidermis.". Exp. Dermatol. 15 (6): 469–77. doi:10.1111/j.1600-0625.2006.00433.x. PMID 16689864. 
  • Babini E, Bertini I, Capozzi F, et al. (2006). "A structural and dynamic characterization of the EF-hand protein CLSP.". Structure 14 (6): 1029–38. doi:10.1016/j.str.2006.04.004. PMID 16765896. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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