Talk:Caffeic acid
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[edit] Contradiction
This compound is listed as both carcinogenic and anticarcinogenic. --Ccroberts 00:32, 23 June 2006 (UTC)
I'm not totally sure that it does. In introduction to the article, it lists it as a carcinogenic inhibitor, and then in the Pharmaceutical Uses section, it discusses that this acid was perceived to be carcinogenic, but has been shown to overall be anticarcinogenic. (If this has been fixed, then the "Contradiction" tag should be removed) --Person man345 9:45, 05 November 2006 (EST)
- The article says that it is carcinogenic in rats (because of bacteria present in a rat's gut causing carcinogenic metabolites?), so it should be stated that it is non-carcinogenic in humans, but carcinogenic in rats. --Mark PEA 19:55, 18 November 2006 (UTC)
- there are lots of different cancers; what causes one may cure another 198.207.0.5 22:17, 17 January 2007 (UTC)
[edit] Carbolic Acid
Carbolic acid is an old name for phenol, which is technically an alcohol. Caffeic acid is a phenolic compound, a derivative of phenol, but not phenol and therefore not previously known a carbolic acid
[edit] Contradiction
In the carcinogenicity study, slightly increased incidences of forestomach papillomas were found in the sesamol- (15.8%), caffeic acid- (14.8%), catechol- (3%) and 4-MP- (11.5%) treated groups as compared with basal diet (0%), and a significant increase was observed with the five antioxidants in combination (42.9%, P < 0.001).M Hirose, Y Takesada, H Tanaka, S Tamano, T Kato and T Shirai (1998). "Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4- methoxyphenol and catechol at low doses, either alone or in combination, and modulation of their effects in a rat medium-term multi- organ carcinogenesis model". Carcinogenesis 19: 207-212.
This simply contradicts the sentence in Pharmaceutical Uses, refering to this publication, i will change this sentence back to increase.--Stone 11:33, 27 June 2007 (UTC)
