CADPS

From Wikipedia, the free encyclopedia

Ca2+-dependent secretion activator

PDB rendering based on 1wi1.

Available structures: 1wi1

Identifiers

Symbol(s)

CADPS; CAPS; CAPS1; KIAA1121

External IDs

OMIM: 604667 MGI: 1350922 HomoloGene: 2755

Gene ontology
Molecular Function:	• calcium ion binding • protein binding • lipid binding
Cellular Component:	• cytosol • membrane • cytoplasmic vesicle • synapse
Biological Process:	• exocytosis • protein transport • vesicle organization and biogenesis • catecholamine secretion

Orthologs

Human

Mouse

Refseq

NM_003716 (mRNA)
NP_003707 (protein)

NM_001042617 (mRNA)
NP_001036082 (protein)

Location

Chr 3: 62.36 - 62.84 Mb

Chr 14: 11.17 - 11.62 Mb

Pubmed search

[1]

[2]

Ca2+-dependent secretion activator, also known as CADPS, is a human gene.^[1]

CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.^[1]

[edit] References

^ ^a ^b Entrez Gene: CADPS Ca2+-dependent secretion activator.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
Nishizaki T, Walent JH, Kowalchyk JA, Martin TF (1992). "A key role for a 145-kDa cytosolic protein in the stimulation of Ca(2+)-dependent secretion by protein kinase C.". J. Biol. Chem. 267 (33): 23972-81. PMID 1429734.
Walent JH, Porter BW, Martin TF (1992). "A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells.". Cell 70 (5): 765-75. PMID 1516133.
Ann K, Kowalchyk JA, Loyet KM, Martin TF (1997). "Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis.". J. Biol. Chem. 272 (32): 19637-40. PMID 9289490.
Loyet KM, Kowalchyk JA, Chaudhary A, et al. (1998). "Specific binding of phosphatidylinositol 4,5-bisphosphate to calcium-dependent activator protein for secretion (CAPS), a potential phosphoinositide effector protein for regulated exocytosis.". J. Biol. Chem. 273 (14): 8337-43. PMID 9525942.
Berwin B, Floor E, Martin TF (1998). "CAPS (mammalian UNC-31) protein localizes to membranes involved in dense-core vesicle exocytosis.". Neuron 21 (1): 137-45. PMID 9697858.
Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.". DNA Res. 6 (5): 329-36. PMID 10574461.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773-84. doi:10.1101/gr.406902. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Cisternas FA, Vincent JB, Scherer SW, Ray PN (2003). "Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family.". Genomics 81 (3): 279-91. PMID 12659812.
Speidel D, Varoqueaux F, Enk C, et al. (2004). "A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function.". J. Biol. Chem. 278 (52): 52802-9. doi:10.1074/jbc.M304727200. PMID 14530279.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Binda AV, Kabbani N, Levenson R (2005). "Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS).". Biochem. Pharmacol. 69 (10): 1451-61. doi:10.1016/j.bcp.2005.02.015. PMID 15857609.