CADPS2

From Wikipedia, the free encyclopedia

Ca2+-dependent activator protein for secretion 2

Identifiers

CADPS2; FLJ40851; KIAA1591

External IDs

OMIM: 609978 MGI: 2443963 HomoloGene: 23060

Gene ontology
Molecular Function:	• calcium ion binding • protein binding • lipid binding
Cellular Component:	• cytoplasmic membrane-bound vesicle • presynaptic membrane • synapse • postsynaptic membrane
Biological Process:	• exocytosis • protein transport • positive regulation of exocytosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001009571 (mRNA)
NP_001009571 (protein)

NM_153163 (mRNA)
NP_694803 (protein)

Location

Chr 7: 121.75 - 122.31 Mb

Chr 6: 23.21 - 23.79 Mb

Pubmed search

[1]

[2]

Ca2+-dependent activator protein for secretion 2, also known as CADPS2, is a human gene.^[1]

[edit] References

^ Entrez Gene: CADPS2 Ca2+-dependent activator protein for secretion 2.

[edit] Further reading

Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273–81. PMID 10997877.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Cisternas FA, Vincent JB, Scherer SW, Ray PN (2003). "Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family.". Genomics 81 (3): 279–91. PMID 12659812.
Speidel D, Varoqueaux F, Enk C, et al. (2004). "A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function.". J. Biol. Chem. 278 (52): 52802–9. doi:10.1074/jbc.M304727200. PMID 14530279.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Binda AV, Kabbani N, Levenson R (2005). "Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS).". Biochem. Pharmacol. 69 (10): 1451–61. doi:10.1016/j.bcp.2005.02.015. PMID 15857609.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Sadakata T, Washida M, Iwayama Y, et al. (2007). "Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients.". J. Clin. Invest. 117 (4): 931–43. doi:10.1172/JCI29031. PMID 17380209.