CADM3

From Wikipedia, the free encyclopedia

Cell adhesion molecule 3

Identifiers

CADM3; BIgR; FLJ10698; IGSF4B; NECL1; Necl-1; TSLL1; synCAM3

External IDs

OMIM: 609743 MGI: 2137858 HomoloGene: 10919

Gene ontology
Molecular Function:	• calcium ion binding • protein binding • protein homodimerization activity
Cellular Component:	• intercellular junction • membrane • integral to membrane
Biological Process:	• cell adhesion • homophilic cell adhesion • heterophilic cell adhesion

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_021189 (mRNA)
NP_067012 (protein)

XM_994117 (mRNA)
XP_999211 (protein)

Location

n/a

Chr 1: 175.17 - 175.2 Mb

Pubmed search

[1]

[2]

Cell adhesion molecule 3, also known as CADM3, is a human gene.^[1]

IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: CADM3 cell adhesion molecule 3.

[edit] Further reading

Fukuhara H, Kuramochi M, Nobukuni T, et al. (2001). "Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins.". Oncogene 20 (38): 5401–7. doi:10.1038/sj.onc.1204696. PMID 11536053.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Shingai T, Ikeda W, Kakunaga S, et al. (2003). "Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells.". J. Biol. Chem. 278 (37): 35421–7. doi:10.1074/jbc.M305387200. PMID 12826663.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Fukami T, Satoh H, Williams YN, et al. (2004). "Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2).". Gene 323: 11–8. PMID 14659875.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
Kakunaga S, Ikeda W, Itoh S, et al. (2005). "Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes.". J. Cell. Sci. 118 (Pt 6): 1267–77. doi:10.1242/jcs.01656. PMID 15741237.
Zhou Y, Du G, Hu X, et al. (2005). "Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane.". Biochim. Biophys. Acta 1669 (2): 142–54. doi:10.1016/j.bbamem.2005.01.013. PMID 15893517.
Dong X, Xu F, Gong Y, et al. (2006). "Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule.". J. Biol. Chem. 281 (15): 10610–7. doi:10.1074/jbc.M513459200. PMID 16467305.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.