CABYR

From Wikipedia, the free encyclopedia

Calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)

Identifiers

CABYR; CBP86; FSP-2; MGC9117

External IDs

MGI: 1918382 HomoloGene: 49299

Gene ontology
Molecular Function:	• structural molecule activity • calcium ion binding • cAMP-dependent protein kinase regulator activity
Cellular Component:	• nucleus • cytoskeleton • microtubule-based flagellum
Biological Process:	• signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012189 (mRNA)
NP_036321 (protein)

NM_001042418 (mRNA)
NP_001035883 (protein)

Location

Chr 18: 19.97 - 20 Mb

Chr 18: 12.88 - 12.9 Mb

Pubmed search

[1]

[2]

Calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2), also known as CABYR, is a human gene.^[1]

To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Transcript variants of this gene encode multiple protein isoforms. An additional transcript and isoform has not been fully characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: CABYR calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2).

[edit] Further reading

Fouquet JP, Kann ML (1995). "The cytoskeleton of mammalian spermatozoa.". Biol. Cell 81 (2): 89–93. PMID 7849610.
Visconti PE, Westbrook VA, Chertihin O, et al. (2002). "Novel signaling pathways involved in sperm acquisition of fertilizing capacity.". J. Reprod. Immunol. 53 (1-2): 133–50. PMID 11730911.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Naaby-Hansen S, Mandal A, Wolkowicz MJ, et al. (2002). "CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation.". Dev. Biol. 242 (2): 236–54. doi:10.1006/dbio.2001.0527. PMID 11820818.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ficarro S, Chertihin O, Westbrook VA, et al. (2003). "Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation.". J. Biol. Chem. 278 (13): 11579–89. doi:10.1074/jbc.M202325200. PMID 12509440.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hsu HC, Lee YL, Cheng TS, et al. (2005). "Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain.". Biochem. Biophys. Res. Commun. 329 (3): 1108–17. doi:10.1016/j.bbrc.2005.02.089. PMID 15752768.
Kim YH, Jha KN, Mandal A, et al. (2005). "Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A.". Dev. Biol. 286 (1): 46–56. doi:10.1016/j.ydbio.2005.07.005. PMID 16139264.
Luo C, Xiao X, Liu D, et al. (2007). "CABYR is a novel cancer-testis antigen in lung cancer.". Clin. Cancer Res. 13 (4): 1288–97. doi:10.1158/1078-0432.CCR-06-1742. PMID 17317841.