CABLES1

From Wikipedia, the free encyclopedia

Cdk5 and Abl enzyme substrate 1

Identifiers

CABLES1; FLJ35924; HsT2563

External IDs

OMIM: 609194 MGI: 1927065 HomoloGene: 11097

Gene ontology
Molecular Function:	• protein binding • cyclin-dependent protein kinase regulator activity
Cellular Component:	• nucleus
Biological Process:	• cell cycle • nervous system development • regulation of cell division • regulation of cell cycle

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_138375 (mRNA)
NP_612384 (protein)

NM_022021 (mRNA)
NP_071304 (protein)

Location

Chr 18: 18.97 - 19.09 Mb

n/a

Pubmed search

[1]

[2]

Cdk5 and Abl enzyme substrate 1, also known as CABLES1, is a human gene.^[1]

CABLES1 is a cyclin-dependent kinase (CDK)-binding protein that plays a role in proliferation and/or differentiation (Zukerberg et al., 2004).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: CABLES1 Cdk5 and Abl enzyme substrate 1.

[edit] Further reading

Matsuoka M, Matsuura Y, Semba K, Nishimoto I (2000). "Molecular cloning of a cyclin-like protein associated with cyclin-dependent kinase 3 (cdk 3) in vivo.". Biochem. Biophys. Res. Commun. 273 (2): 442-7. doi:10.1006/bbrc.2000.2965. PMID 10873625.
Zukerberg LR, Patrick GN, Nikolic M, et al. (2000). "Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth.". Neuron 26 (3): 633-46. PMID 10896159.
Yamochi T, Nishimoto I, Okuda T, Matsuoka M (2001). "ik3-1/Cables is associated with Trap and Pctaire2.". Biochem. Biophys. Res. Commun. 286 (5): 1045-50. doi:10.1006/bbrc.2001.5493. PMID 11527406.
Wu CL, Kirley SD, Xiao H, et al. (2001). "Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers.". Cancer Res. 61 (19): 7325-32. PMID 11585773.
Tsuji K, Mizumoto K, Yamochi T, et al. (2002). "Differential effect of ik3-1/cables on p53- and p73-induced cell death.". J. Biol. Chem. 277 (4): 2951-7. doi:10.1074/jbc.M108535200. PMID 11706030.
Yamochi T, Semba K, Tsuji K, et al. (2002). "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3).". Eur. J. Biochem. 268 (23): 6076-82. PMID 11733001.
Sato H, Nishimoto I, Matsuoka M (2002). "ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl.". Biochim. Biophys. Acta 1574 (2): 157-63. PMID 11955625.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Tan D, Kirley S, Li Q, et al. (2003). "Loss of cables protein expression in human non-small cell lung cancer: a tissue microarray study.". Hum. Pathol. 34 (2): 143-9. doi:10.1053/hupa.2003.26. PMID 12612882.
Dong Q, Kirley S, Rueda B, et al. (2004). "Loss of cables, a novel gene on chromosome 18q, in ovarian cancer.". Mod. Pathol. 16 (9): 863-8. doi:10.1097/01.MP.0000084434.88269.0A. PMID 13679449.
Matsuoka M, Sudo H, Tsuji K, et al. (2004). "ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways.". Biochem. Biophys. Res. Commun. 312 (2): 520-9. PMID 14637168.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Zukerberg LR, DeBernardo RL, Kirley SD, et al. (2004). "Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer.". Cancer Res. 64 (1): 202-8. PMID 14729625.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Zhang H, Duan HO, Kirley SD, et al. (2006). "Aberrant splicing of cables gene, a CDK regulator, in human cancers.". Cancer Biol. Ther. 4 (11): 1211-5. PMID 16177568.
Nusbaum C, Zody MC, Borowsky ML, et al. (2005). "DNA sequence and analysis of human chromosome 18.". Nature 437 (7058): 551-5. doi:10.1038/nature03983. PMID 16177791.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.
Hirao N, Sato S, Gotoh T, et al. (2007). "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation.". FEBS Lett. 580 (27): 6464-70. doi:10.1016/j.febslet.2006.10.065. PMID 17101133.