CABIN1

From Wikipedia, the free encyclopedia

Calcineurin binding protein 1

PDB rendering based on 1n6j.

Available structures: 1n6j

Identifiers

Symbol(s)

CABIN1; CAIN; KIAA0330

External IDs

OMIM: 604251 MGI: 1298375 HomoloGene: 49307

Gene ontology
Molecular Function:	• protein phosphatase inhibitor activity • binding
Cellular Component:	• nucleus
Biological Process:	• cell surface receptor linked signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_012295 (mRNA)
NP_036427 (protein)

NM_172549 (mRNA)
NP_766137 (protein)

Location

Chr 22: 22.74 - 22.9 Mb

Chr 10: 75.09 - 75.21 Mb

Pubmed search

[1]

[2]

Calcineurin binding protein 1, also known as CABIN1, is a human gene.^[1]

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. At least four alternatively spliced transcripts have been found for this gene, but the full-length nature of most of them has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: CABIN1 calcineurin binding protein 1.

[edit] Further reading

Liu JO (2004). "Endogenous protein inhibitors of calcineurin.". Biochem. Biophys. Res. Commun. 311 (4): 1103–9. PMID 14623296.
Laherty CD, Yang WM, Sun JM, et al. (1997). "Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression.". Cell 89 (3): 349–56. PMID 9150134.
Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. PMID 9205841.
Sun L, Youn HD, Loh C, et al. (1998). "Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes.". Immunity 8 (6): 703–11. PMID 9655484.
Youn HD, Sun L, Prywes R, Liu JO (1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2.". Science 286 (5440): 790–3. PMID 10531067.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Youn HD, Grozinger CM, Liu JO (2000). "Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4.". J. Biol. Chem. 275 (29): 22563–7. doi:10.1074/jbc.C000304200. PMID 10825153.
Lai MM, Luo HR, Burnett PE, et al. (2000). "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis.". J. Biol. Chem. 275 (44): 34017–20. doi:10.1074/jbc.C000429200. PMID 10931822.
Youn HD, Liu JO (2000). "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2.". Immunity 13 (1): 85–94. PMID 10933397.
Esau C, Boes M, Youn HD, et al. (2001). "Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells.". J. Exp. Med. 194 (10): 1449–59. PMID 11714752.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Han A, Pan F, Stroud JC, et al. (2003). "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2.". Nature 422 (6933): 730–4. doi:10.1038/nature01555. PMID 12700764.
Tagami H, Ray-Gallet D, Almouzni G, Nakatani Y (2004). "Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis.". Cell 116 (1): 51–61. PMID 14718166.
Rodríguez A, Martínez-Martínez S, López-Maderuelo MD, et al. (2005). "The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT.". J. Biol. Chem. 280 (11): 9980–4. doi:10.1074/jbc.C400401200. PMID 15671033.
Li XN, Li YL, Liu GB, Ding YQ (2007). "Selection of choriocarcinoma-associated genes using bioinformatics.". Di Yi Jun Yi Da Xue Xue Bao 25 (1): 1–6. PMID 15683985.
Pan F, Means AR, Liu JO (2005). "Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation.". EMBO J. 24 (12): 2104–13. doi:10.1038/sj.emboj.7600685. PMID 15902271.
Jang H, Cho EJ, Youn HD (2007). "A new calcineurin inhibition domain in Cabin1.". Biochem. Biophys. Res. Commun. 359 (1): 129–35. doi:10.1016/j.bbrc.2007.05.066. PMID 17531200.