CA8

From Wikipedia, the free encyclopedia

Carbonic anhydrase VIII

Identifiers

CA8; CA-VIII; CALS; CARP; MGC120502; MGC99509

External IDs

OMIM: 114815 MGI: 88253 HomoloGene: 20861

Gene ontology
Molecular Function:	• carbonate dehydratase activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• cytoplasm
Biological Process:	• one-carbon compound metabolic process • phosphoinositide-mediated signaling

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004056 (mRNA)
NP_004047 (protein)

NM_007592 (mRNA)
NP_031618 (protein)

Location

Chr 8: 61.26 - 61.36 Mb

Chr 4: 8.07 - 8.17 Mb

Pubmed search

[1]

[2]

Carbonic anhydrase VIII, also known as CA8, is a human gene.^[1]

The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form.^[1]

[edit] References

^ ^a ^b Entrez Gene: CA8 carbonic anhydrase VIII.

[edit] Further reading

Bergenhem NC, Sait SS, Eddy RL, et al. (1995). "Assignment of the gene for human carbonic anhydrase VIII(CA8) to chromosome 8q11-->q12.". Cytogenet. Cell Genet. 71 (3): 299–300. PMID 7587398.
Kelly C, Nógrádi A, Walker R, et al. (1995). "Lurching, reeling, waddling and staggering in mice--is carbonic anhydrase (CA) VIII a candidate gene?". Biochem. Soc. Trans. 22 (3): 359S. PMID 7821612.
Skaggs LA, Bergenhem NC, Venta PJ, Tashian RE (1993). "The deduced amino acid sequence of human carbonic anhydrase-related protein (CARP) is 98% identical to the mouse homologue.". Gene 126 (2): 291–2. PMID 8482548.
Sjöblom B, Elleby B, Wallgren K, et al. (1997). "Two point mutations convert a catalytically inactive carbonic anhydrase-related protein (CARP) to an active enzyme.". FEBS Lett. 398 (2-3): 322–5. PMID 8977131.
Taniuchi K, Nishimori I, Takeuchi T, et al. (2002). "Developmental expression of carbonic anhydrase-related proteins VIII, X, and XI in the human brain.". Neuroscience 112 (1): 93–9. PMID 12044474.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Akisawa Y, Nishimori I, Taniuchi K, et al. (2003). "Expression of carbonic anhydrase-related protein CA-RP VIII in non-small cell lung cancer.". Virchows Arch. 442 (1): 66–70. doi:10.1007/s00428-002-0721-y. PMID 12536316.
Hirota J, Ando H, Hamada K, Mikoshiba K (2003). "Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1.". Biochem. J. 372 (Pt 2): 435–41. doi:10.1042/BJ20030110. PMID 12611586.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Nishikata M, Nishimori I, Taniuchi K, et al. (2007). "Carbonic anhydrase-related protein VIII promotes colon cancer cell growth.". Mol. Carcinog. 46 (3): 208–14. doi:10.1002/mc.20264. PMID 17219437.