CA12

From Wikipedia, the free encyclopedia

Carbonic anhydrase XII

PDB rendering based on 1jcz.

Available structures: 1jcz, 1jd0

Identifiers

Symbol(s)

CA12; CAXII; FLJ20151; HsT18816

External IDs

OMIM: 603263 MGI: 1923709 HomoloGene: 20327

Gene ontology
Molecular Function:	• carbonate dehydratase activity • zinc ion binding • lyase activity • metal ion binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• one-carbon compound metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001218 (mRNA)
NP_001209 (protein)

NM_178396 (mRNA)
NP_848483 (protein)

Location

Chr 15: 61.4 - 61.46 Mb

Chr 9: 66.51 - 66.57 Mb

Pubmed search

[1]

[2]

Carbonic anhydrase XII, also known as CA12, is a human gene.^[1]

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Two transcript variants encoding different isoforms have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: CA12 carbonic anhydrase XII.

[edit] Further reading

Sahin U, Türeci O, Schmitt H, et al. (1996). "Human neoplasms elicit multiple specific immune responses in the autologous host.". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11810–3. PMID 8524854.
Türeci O, Sahin U, Vollmar E, et al. (1998). "Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers.". Proc. Natl. Acad. Sci. U.S.A. 95 (13): 7608–13. PMID 9636197.
Ivanov SV, Kuzmin I, Wei MH, et al. (1998). "Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes.". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12596–601. PMID 9770531.
Fujikawa-Adachi K, Nishimori I, Taguchi T, Onishi S (1999). "Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1.". Genomics 61 (1): 74–81. doi:10.1006/geno.1999.5938. PMID 10512682.
Karhumaa P, Parkkila S, Türeci O, et al. (2000). "Identification of carbonic anhydrase XII as the membrane isozyme expressed in the normal human endometrial epithelium.". Mol. Hum. Reprod. 6 (1): 68–74. PMID 10611263.
Kivelä A, Parkkila S, Saarnio J, et al. (2000). "Expression of a novel transmembrane carbonic anhydrase isozyme XII in normal human gut and colorectal tumors.". Am. J. Pathol. 156 (2): 577–84. PMID 10666387.
Kivelä AJ, Parkkila S, Saarnio J, et al. (2001). "Expression of transmembrane carbonic anhydrase isoenzymes IX and XII in normal human pancreas and pancreatic tumours.". Histochem. Cell Biol. 114 (3): 197–204. PMID 11083462.
Parkkila S, Parkkila AK, Saarnio J, et al. (2001). "Expression of the membrane-associated carbonic anhydrase isozyme XII in the human kidney and renal tumors.". J. Histochem. Cytochem. 48 (12): 1601–8. PMID 11101628.
Wykoff CC, Beasley N, Watson PH, et al. (2001). "Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast.". Am. J. Pathol. 158 (3): 1011–9. PMID 11238049.
Karhumaa P, Kaunisto K, Parkkila S, et al. (2001). "Expression of the transmembrane carbonic anhydrases, CA IX and CA XII, in the human male excurrent ducts.". Mol. Hum. Reprod. 7 (7): 611–6. PMID 11420383.
Whittington DA, Waheed A, Ulmasov B, et al. (2001). "Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells.". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9545–50. doi:10.1073/pnas.161301298. PMID 11493685.
Kivela AJ, Saarnio J, Karttunen TJ, et al. (2001). "Differential expression of cytoplasmic carbonic anhydrases, CA I and II, and membrane-associated isozymes, CA IX and XII, in normal mucosa of large intestine and in colorectal tumors.". Dig. Dis. Sci. 46 (10): 2179–86. PMID 11680594.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Liao SY, Ivanov S, Ivanova A, et al. (2003). "Expression of cell surface transmembrane carbonic anhydrase genes CA9 and CA12 in the human eye: overexpression of CA12 (CAXII) in glaucoma.". J. Med. Genet. 40 (4): 257–61. PMID 12676895.
Leppilampi M, Saarnio J, Karttunen TJ, et al. (2003). "Carbonic anhydrase isozymes IX and XII in gastric tumors.". World J. Gastroenterol. 9 (7): 1398–403. PMID 12854129.
Kyllönen MS, Parkkila S, Rajaniemi H, et al. (2003). "Localization of carbonic anhydrase XII to the basolateral membrane of H+-secreting cells of mouse and rat kidney.". J. Histochem. Cytochem. 51 (9): 1217–24. PMID 12923247.
Tarun AS, Bryant B, Zhai W, et al. (2004). "Gene expression for carbonic anhydrase isoenzymes in human nasal mucosa.". Chem. Senses 28 (7): 621–9. PMID 14578124.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kivela AJ, Parkkila S, Saarnio J, et al. (2005). "Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa.". World J. Gastroenterol. 11 (17): 2616–25. PMID 15849821.