CA11

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Carbonic anhydrase XI
Identifiers
Symbol(s) CA11; CA-RP XI; CARP2
External IDs OMIM: 604644 MGI: 1336193 HomoloGene: 36061
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 770 12348
Ensembl ENSG00000063180 ENSMUSG00000003273
Uniprot O75493 Q3USV1
Refseq NM_001217 (mRNA)
NP_001208 (protein)		 NM_009800 (mRNA)
NP_033930 (protein)
Location Chr 19: 53.83 - 53.84 Mb Chr 7: 45.57 - 45.57 Mb
Pubmed search [1] [2]

Carbonic anhydrase XI, also known as CA11, is a human gene.[1]

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system.[1]

[edit] References

  1. ^ a b Entrez Gene: CA11 carbonic anhydrase XI.

[edit] Further reading

  • Lovejoy DA, Hewett-Emmett D, Porter CA, et al. (1999). "Evolutionarily conserved, "acatalytic" carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3.". Genomics 54 (3): 484-93. doi:10.1006/geno.1998.5585. PMID 9878252. 
  • Bellingham J, Gregory-Evans K, Gregory-Evans CY (1999). "Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3.". Biochem. Biophys. Res. Commun. 253 (2): 364-7. doi:10.1006/bbrc.1998.9449. PMID 9878543. 
  • Fujikawa-Adachi K, Nishimori I, Taguchi T, et al. (1999). "cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI.". Biochim. Biophys. Acta 1431 (2): 518-24. PMID 10350627. 
  • Okamoto N, Fujikawa-Adachi K, Nishimori I, et al. (2001). "cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain.". Biochim. Biophys. Acta 1518 (3): 311-6. PMID 11311946. 
  • Taniuchi K, Nishimori I, Takeuchi T, et al. (2002). "Developmental expression of carbonic anhydrase-related proteins VIII, X, and XI in the human brain.". Neuroscience 112 (1): 93-9. PMID 12044474. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070-80. doi:10.1021/pr0502065. PMID 16335952. 
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