C8orf4

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Chromosome 8 open reading frame 4
Identifiers
Symbol(s) C8orf4; TC1; MGC22806; TC-1; hTC-1
External IDs OMIM: 607702 MGI: 1916318 HomoloGene: 10590
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 56892 69068
Ensembl ENSG00000176907 ENSMUSG00000056313
Uniprot Q9NR00 Q9D915
Refseq NM_020130 (mRNA)
NP_064515 (protein)		 NM_026931 (mRNA)
NP_081207 (protein)
Location Chr 8: 40.13 - 40.13 Mb Chr 8: 25.9 - 25.9 Mb
Pubmed search [1] [2]

Chromosome 8 open reading frame 4, also known as C8orf4, is a human gene.[1]

This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes.[1]

[edit] References

  1. ^ a b Entrez Gene: C8orf4 chromosome 8 open reading frame 4.

[edit] Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548. 
  • Chua EL, Young L, Wu WM, et al. (2001). "Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer.". Genomics 69 (3): 342-7. doi:10.1006/geno.2000.6348. PMID 11056052. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Sunde M, McGrath KC, Young L, et al. (2004). "TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer.". Cancer Res. 64 (8): 2766-73. PMID 15087392. 
  • Friedman JB, Brunschwig EB, Platzer P, et al. (2004). "C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer.". Int. J. Cancer 111 (1): 72-5. doi:10.1002/ijc.20235. PMID 15185345. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Jung Y, Bang S, Choi K, et al. (2006). "TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby.". Cancer Res. 66 (2): 723-8. doi:10.1158/0008-5472.CAN-05-3124. PMID 16424001. 
  • Kim B, Koo H, Yang S, et al. (2007). "TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer.". Clin. Cancer Res. 12 (11 Pt 1): 3541-8. doi:10.1158/1078-0432.CCR-05-2440. PMID 16740781. 
  • Yang ZQ, Streicher KL, Ray ME, et al. (2007). "Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer.". Cancer Res. 66 (24): 11632-43. doi:10.1158/0008-5472.CAN-06-2946. PMID 17178857. 
  • Yang ZQ, Moffa AB, Haddad R, et al. (2007). "Transforming properties of TC-1 in human breast cancer: interaction with FGFR2 and beta-catenin signaling pathways.". Int. J. Cancer 121 (6): 1265-73. doi:10.1002/ijc.22831. PMID 17520678. 
  • Park J, Jung Y, Kim J, et al. (2007). "TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response.". Biochem. Biophys. Res. Commun. 360 (2): 447-52. doi:10.1016/j.bbrc.2007.06.077. PMID 17603013. 
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