C6orf25

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Chromosome 6 open reading frame 25
Identifiers
Symbol(s) C6orf25; G6b; MGC142279; MGC142281; NG31
External IDs OMIM: 606520 MGI: 2146995 HomoloGene: 82249
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 80739 106722
Ensembl ENSG00000096148 ENSMUSG00000073414
Uniprot O95866 n/a
Refseq NM_025260 (mRNA)
NP_079536 (protein)		 NM_001033221 (mRNA)
NP_001028393 (protein)
Location Chr c6_COX: 31.83 - 31.83 Mb Chr 17: 34.67 - 34.67 Mb
Pubmed search [1] [2]

Chromosome 6 open reading frame 25, also known as C6orf25, is a human gene.[1]

This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: C6orf25 chromosome 6 open reading frame 25.

[edit] Further reading

  • Ribas G, Neville M, Wixon JL, et al. (1999). "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region.". J. Immunol. 163 (1): 278–87. PMID 10384126. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863. 
  • de Vet EC, Aguado B, Campbell RD (2001). "G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2.". J. Biol. Chem. 276 (45): 42070–6. doi:10.1074/jbc.M103214200. PMID 11544253. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
  • Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMID 14656967. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • de Vet EC, Newland SA, Lyons PA, et al. (2005). "The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin.". FEBS Lett. 579 (11): 2355–8. doi:10.1016/j.febslet.2005.03.032. PMID 15848171. 
  • Newland SA, Macaulay IC, Floto AR, et al. (2007). "The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro.". Blood 109 (11): 4806–9. doi:10.1182/blood-2006-09-047449. PMID 17311996. 
  • Li J, Cadeiras M, Prinz von Bayern M, et al. (2007). "G6b-B cell surface inhibitory receptor expression is highly restricted to CD4+ T-cells and induced by interleukin-4-activated STAT6 pathway.". Hum. Immunol. 68 (8): 708–14. doi:10.1016/j.humimm.2007.04.008. PMID 17678728. 
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