C2orf3

From Wikipedia, the free encyclopedia

Chromosome 2 open reading frame 3

Identifiers

C2orf3; DNABF; GCF; TCF9

External IDs

OMIM: 189901 MGI: 2141656 HomoloGene: 2411

Gene ontology
Molecular Function:	• transcription factor activity • RNA polymerase II transcription factor activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003203 (mRNA)
NP_003194 (protein)

NM_177884 (mRNA)
NP_808552 (protein)

Location

Chr 2: 75.74 - 75.8 Mb

Chr 6: 81.89 - 81.92 Mb

Pubmed search

[1]

[2]

Chromosome 2 open reading frame 3, also known as C2orf3, is a human gene.^[1]

The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: C2orf3 chromosome 2 open reading frame 3.

[edit] Further reading

Johnson AC, Kageyama R, Popescu NC, Pastan I (1992). "Expression and chromosomal localization of the gene for the human transcriptional repressor GCF.". J. Biol. Chem. 267 (3): 1689-94. PMID 1370479.
Kageyama R, Pastan I (1990). "Molecular cloning and characterization of a human DNA binding factor that represses transcription.". Cell 59 (5): 815-25. PMID 2556218.
Mao P (1999). "[Revisions of the cDNA and primary protein structure of human transcription factor GCF]". Hokkaido Igaku Zasshi 74 (4): 315-30. PMID 10480038.
Takimoto M, Mao P, Wei G, et al. (1999). "Molecular analysis of the GCF gene identifies revisions to the cDNA and amino acid sequences(1).". Biochim. Biophys. Acta 1447 (1): 125-31. PMID 10500253.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Anthoni H, Zucchelli M, Matsson H, et al. (2007). "A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia.". Hum. Mol. Genet. 16 (6): 667-77. doi:10.1093/hmg/ddm009. PMID 17309879.