C2orf28

From Wikipedia, the free encyclopedia

Chromosome 2 open reading frame 28

Identifiers

C2orf28; p18; APR--3; APR-3; APR3; HSPC013; PRO240

External IDs

MGI: 1918918 HomoloGene: 15412

Gene ontology
Molecular Function:	• molecular_function
Cellular Component:	• cellular_component • membrane • integral to membrane
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016085 (mRNA)
NP_057169 (protein)

NM_027855 (mRNA)
NP_082131 (protein)

Location

Chr 2: 27.29 - 27.29 Mb

Chr 5: 31.33 - 31.33 Mb

Pubmed search

[1]

[2]

Chromosome 2 open reading frame 28, also known as C2orf28, is a human gene.^[1]

This gene is thought to be involved in apoptosis, and may also be involved in hematopoietic development and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: C2orf28 chromosome 2 open reading frame 28.

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Zhu F, Yan W, Zhao ZL, et al. (2001). "Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes.". BioTechniques 29 (2): 310–3. PMID 10948432.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Yang G, Yu F, Fu H, et al. (2007). "Identification of the distinct promoters for the two transcripts of apoptosis related protein 3 and their transcriptional regulation by NFAT and NFkappaB.". Mol. Cell. Biochem. 302 (1-2): 187–94. doi:10.1007/s11010-007-9440-7. PMID 17387583.
Yu F, Yang G, Zhao Z, et al. (2007). "Apoptosis related protein 3, an ATRA-upregulated membrane protein arrests the cell cycle at G1/S phase by decreasing the expression of cyclin D1.". Biochem. Biophys. Res. Commun. 358 (4): 1041–6. doi:10.1016/j.bbrc.2007.05.049. PMID 17524364.