C1D

From Wikipedia, the free encyclopedia

Nuclear DNA-binding protein

Identifiers

C1D; MGC12261; MGC14659; SUNCOR

External IDs

Gene ontology
Molecular Function:	• DNA binding
Cellular Component:	• nucleus

Orthologs

Human

Mouse

Entrez

10438

n/a

Refseq

NM_006333 (mRNA)
NP_006324 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Nuclear DNA-binding protein, also known as C1D, is a human gene.^[1]

The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Several alternatively spliced transcript variants of this gene have been described, but the full length nature of some of these variants has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: C1D nuclear DNA-binding protein.

[edit] Further reading

Schilders G, Egberts WV, Raijmakers R, Pruijn GJ (2007). "C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome.". Arthritis Rheum. 56 (7): 2449-54. doi:10.1002/art.22710. PMID 17599775.
Schilders G, van Dijk E, Pruijn GJ (2007). "C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing.". Nucleic Acids Res. 35 (8): 2564-72. doi:10.1093/nar/gkm082. PMID 17412707.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Rothbarth K, Stammer H, Werner D. "Proteasome-mediated degradation antagonizes critical levels of the apoptosis-inducing C1D protein." 2 (1): 12. PMID 12379155.
Erdemir T, Bilican B, Oncel D, et al. (2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX).". J. Cell. Sci. 115 (Pt 1): 207-16. PMID 11801738.
Rothbarth K, Hunziker A, Stammer H, Werner D (2001). "Promoter of the gene encoding the 16 kDa DNA-binding and apoptosis-inducing C1D protein.". Biochim. Biophys. Acta 1518 (3): 271-5. PMID 11311939.
Rothbarth K, Spiess E, Juodka B, et al. (1999). "Induction of apoptosis by overexpression of the DNA-binding and DNA-PK-activating protein C1D.". J. Cell. Sci. 112 ( Pt 13): 2223-32. PMID 10362552.
Haataja L, Groffen J, Heisterkamp N (1999). "Identification of a novel Rac3-interacting protein C1D.". Int. J. Mol. Med. 1 (4): 665-70. PMID 9852280.
Yavuzer U, Smith GC, Bliss T, et al. (1998). "DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D.". Genes Dev. 12 (14): 2188-99. PMID 9679063.
Nehls P, Keck T, Greferath R, et al. (1998). "cDNA cloning, recombinant expression and characterization of polypetides with exceptional DNA affinity.". Nucleic Acids Res. 26 (5): 1160-6. PMID 9469821.
Zamir I, Dawson J, Lavinsky RM, et al. (1998). "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14400-5. PMID 9405624.