C19orf2

From Wikipedia, the free encyclopedia

Chromosome 19 open reading frame 2

Identifiers

C19orf2; RMP; NNX3; FLJ10575; URI

External IDs

OMIM: 603494 MGI: 1342294 HomoloGene: 2813

Gene ontology
Molecular Function:	• transcription corepressor activity • protein binding
Cellular Component:	• nucleus • DNA-directed RNA polymerase II, core complex • cytoplasm • prefoldin complex
Biological Process:	• regulation of transcription from RNA polymerase II promoter • protein folding • response to virus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_003796 (mRNA)
NP_003787 (protein)

NM_011274 (mRNA)
NP_035404 (protein)

Location

Chr 19: 35.11 - 35.2 Mb

Chr 7: 37.67 - 37.73 Mb

Pubmed search

[1]

[2]

Chromosome 19 open reading frame 2, also known as C19orf2, is a human gene.^[1]

The protein encoded by this gene binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the chromatin structure. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: C19orf2 chromosome 19 open reading frame 2.

[edit] Further reading

Dorjsuren D, Lin Y, Wei W, et al. (1998). "RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein.". Mol. Cell. Biol. 18 (12): 7546-55. PMID 9819440.
Van Leuven F, Torrekens S, Moechars D, et al. (1999). "Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease.". Genomics 54 (3): 511-20. doi:10.1006/geno.1998.5609. PMID 9878255.
Liu L, McKeehan WL (2002). "Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity.". Genomics 79 (1): 124-36. doi:10.1006/geno.2001.6679. PMID 11827465.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wei W, Gu JX, Zhu CQ, et al. (2003). "Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP).". Cell Res. 13 (2): 111-20. doi:10.1038/sj.cr.7290155. PMID 12737519.
Gstaiger M, Luke B, Hess D, et al. (2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI.". Science 302 (5648): 1208-12. doi:10.1126/science.1088401. PMID 14615539.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216.
Delgermaa L, Hayashi N, Dorjsuren D, et al. (2004). "Subcellular localization of RPB5-mediating protein and its putative functional partner.". Mol. Cell. Biol. 24 (19): 8556-66. doi:10.1128/MCB.24.19.8556-8566.2004. PMID 15367675.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.