Butyryl-CoA dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a butyryl-CoA dehydrogenase (EC 1.3.99.2) is an enzyme that catalyzes the chemical reaction

butanoyl-CoA + acceptor 2-butenoyl-CoA + reduced acceptor

Thus, the two substrates of this enzyme are butanoyl-CoA and acceptor, whereas its two products are 2-butenoyl-CoA and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is butanoyl-CoA:acceptor 2,3-oxidoreductase. Other names in common use include butyryl dehydrogenase, unsaturated acyl-CoA reductase, ethylene reductase, enoyl-coenzyme A reductase, unsaturated acyl coenzyme A reductase, butyryl coenzyme A dehydrogenase, short-chain acyl CoA dehydrogenase, short-chain acyl-coenzyme A dehydrogenase, 3-hydroxyacyl CoA reductase, and butanoyl-CoA:(acceptor) 2,3-oxidoreductase. This enzyme participates in 3 metabolic pathways: fatty acid metabolism, valine, leucine and isoleucine degradation, and butanoate metabolism. It employs one cofactor, FAD.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1BUC and 1JQI.

[edit] References

• IUBMB entry for 1.3.99.2
• BRENDA references for 1.3.99.2 (Recommended.)
• PubMed references for 1.3.99.2
• PubMed Central references for 1.3.99.2
• Google Scholar references for 1.3.99.2
• Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 447-466.
• MAHLER HR, MACKLER B, GREEN DE (1954). "Studies on metalloflavoproteins. III. Aldehyde oxidase: a molybdoflavoprotein". J. Biol. Chem. 210: 465–80. PMID 13201608. 
• HAUGE JG, CRANE FL, BEINERT H (1956). "On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. III. Palmityl coA dehydrogenase". J. Biol. Chem. 219: 727–33. PMID 13319294. 
• MAHLER HR (1954). "Studies on the fatty acid oxidizing system of animal tissues. IV The prosthetic group of butyryl coenzyme A dehydrogenase". J. Biol. Chem. 206: 13–26. PMID 13130522. 

[edit] External links

The CAS registry number for this enzyme class is 9027-88-7.

• IUBMB entry for 1.3.99.2

• KEGG entry for 1.3.99.2

• BRENDA entry for 1.3.99.2

• NiceZyme view of 1.3.99.2

• EC2PDB: PDB structures for 1.3.99.2

• PRIAM entry for 1.3.99.2

• PUMA2 entry for 1.3.99.2

• IntEnz: Integrated Enzyme entry for 1.3.99.2

• MetaCyc entry for 1.3.99.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004085: butyryl-CoA dehydrogenase

• AMIGO entry for GO code 0004085: butyryl-CoA dehydrogenase