Butyrate-CoA ligase
From Wikipedia, the free encyclopedia
In enzymology, a butyrate-CoA ligase (EC 6.2.1.2) is an enzyme that catalyzes the chemical reaction
- ATP + an acid + CoA AMP + diphosphate + an acyl-CoA
The 3 substrates of this enzyme are ATP, acid, and CoA, whereas its 3 products are AMP, diphosphate, and acyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is butanoate:CoA ligase (AMP-forming). Other names in common use include butyryl-CoA synthetase, fatty acid thiokinase (medium chain), acyl-activating enzyme, fatty acid elongase, fatty acid activating enzyme, fatty acyl coenzyme A synthetase, medium chain acyl-CoA synthetase, butyryl-coenzyme A synthetase, L-(+)-3-hydroxybutyryl CoA ligase, and short-chain acyl-CoA synthetase. This enzyme participates in butanoate metabolism.
[edit] References
- IUBMB entry for 6.2.1.2
- BRENDA references for 6.2.1.2 (Recommended.)
- PubMed references for 6.2.1.2
- PubMed Central references for 6.2.1.2
- Google Scholar references for 6.2.1.2
- MAHLER HR, WAKIL SJ, BOCK RM (1953). "Studies on fatty acid oxidation. I. Enzymatic activation of fatty acids". J. Biol. Chem. 204: 453–68. PMID 13084616.
- Massaro EJ and Lennarz WJ (1965). "The partial purification and characterization of a bacterial fatty acyl coenzyme A synthetase". Biochemistry 4: 85–90. doi: .
- Websterlt JR, Gerowin LD and Rakita L (1965). "Purification and characteristics of a butyryl coenzyme A synthetase from bovine heart mitochondria". J. Biol. Chem. 240: 29–33.
[edit] External links
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- The CAS registry number for this enzyme class is 9080-51-7.