BTRC (gene)

From Wikipedia, the free encyclopedia

Beta-transducin repeat containing

PDB rendering based on 1p22.

Available structures: 1p22

Identifiers

Symbol(s)

BTRC; BETA-TRCP; FBW1A; FBXW1A; FWD1; MGC4643; bTrCP; bTrCP1; betaTrCP

External IDs

OMIM: 603482 MGI: 1338871 HomoloGene: 39330

Gene ontology
Molecular Function:	• protein binding • ligase activity
Cellular Component:	• endoplasmic reticulum
Biological Process:	• ubiquitin-dependent protein catabolic process • ubiquitin cycle • signal transduction • Wnt receptor signaling pathway

Orthologs

Human

Mouse

n/a

Refseq

NM_003939 (mRNA)
NP_003930 (protein)

NM_001037758 (mRNA)
NP_001032847 (protein)

Location

Chr 10: 103.1 - 103.31 Mb

Chr 19: 45.42 - 45.58 Mb

Pubmed search

[1]

[2]

Beta-transducin repeat containing, also known as BTRC, is a human gene.^[1]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.^[1]

[edit] References

^ ^a ^b Entrez Gene: BTRC beta-transducin repeat containing.

[edit] Further reading

Maniatis T (1999). "A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways.". Genes Dev. 13 (5): 505–10. PMID 10072378.
Li L, Li HS, Pauza CD, et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.". Cell Res. 15 (11-12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Margottin F, Bour SP, Durand H, et al. (1998). "A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif.". Mol. Cell 1 (4): 565–74. PMID 9660940.
Yaron A, Hatzubai A, Davis M, et al. (1999). "Identification of the receptor component of the IkappaBalpha-ubiquitin ligase.". Nature 396 (6711): 590–4. doi:10.1038/25159. PMID 9859996.
Winston JT, Strack P, Beer-Romero P, et al. (1999). "The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.". Genes Dev. 13 (3): 270–83. PMID 9990852.
Spencer E, Jiang J, Chen ZJ (1999). "Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP.". Genes Dev. 13 (3): 284–94. PMID 9990853.
Kitagawa M, Hatakeyama S, Shirane M, et al. (1999). "An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin.". EMBO J. 18 (9): 2401–10. doi:10.1093/emboj/18.9.2401. PMID 10228155.
Fujiwara T, Suzuki M, Tanigami A, et al. (1999). "The BTRC gene, encoding a human F-box/WD40-repeat protein, maps to chromosome 10q24-q25.". Genomics 58 (1): 104–5. doi:10.1006/geno.1999.5792. PMID 10331953.
Wu C, Ghosh S (1999). "beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta.". J. Biol. Chem. 274 (42): 29591–4. PMID 10514424.
Cenciarelli C, Chiaur DS, Guardavaccaro D, et al. (1999). "Identification of a family of human F-box proteins.". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
Stone DM, Murone M, Luoh S, et al. (2000). "Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli.". J. Cell. Sci. 112 ( Pt 23): 4437–48. PMID 10564661.
Suzuki H, Chiba T, Suzuki T, et al. (2000). "Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination.". J. Biol. Chem. 275 (4): 2877–84. PMID 10644755.
Read MA, Brownell JE, Gladysheva TB, et al. (2000). "Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha.". Mol. Cell. Biol. 20 (7): 2326–33. PMID 10713156.
Sadot E, Simcha I, Iwai K, et al. (2000). "Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system.". Oncogene 19 (16): 1992–2001. doi:10.1038/sj.onc.1203519. PMID 10803460.
Chiaur DS, Murthy S, Cenciarelli C, et al. (2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors.". Cytogenet. Cell Genet. 88 (3-4): 255–8. PMID 10828603.
Orian A, Gonen H, Bercovich B, et al. (2000). "SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase.". EMBO J. 19 (11): 2580–91. doi:10.1093/emboj/19.11.2580. PMID 10835356.
Strack P, Caligiuri M, Pelletier M, et al. (2000). "SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4.". Oncogene 19 (31): 3529–36. doi:10.1038/sj.onc.1203647. PMID 10918611.
Kleijnen MF, Shih AH, Zhou P, et al. (2000). "The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.". Mol. Cell 6 (2): 409–19. PMID 10983987.