BTN2A2

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Butyrophilin, subfamily 2, member A2
Identifiers
Symbol(s) BTN2A2; BTF2; BT2.2; FLJ41908
External IDs MGI: 3606486 HomoloGene: 56012
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10385 238555
Ensembl ENSG00000124508 ENSMUSG00000053216
Uniprot Q8WVV5 n/a
Refseq NM_006995 (mRNA)
NP_008926 (protein)		 NM_175938 (mRNA)
NP_787952 (protein)
Location Chr 6: 26.49 - 26.5 Mb Chr 13: 23.49 - 23.5 Mb
Pubmed search [1] [2]

Butyrophilin, subfamily 2, member A2, also known as BTN2A2, is a human gene.[1]

Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type 1 receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.[1]

[edit] References

  1. ^ a b Entrez Gene: BTN2A2 butyrophilin, subfamily 2, member A2.

[edit] Further reading

  • Henry J, Miller MM, Pontarotti P (1999). "Structure and evolution of the extended B7 family.". Immunol. Today 20 (6): 285–8. PMID 10354554. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Cavaletto M, Giuffrida MG, Fortunato D, et al. (2003). "A proteomic approach to evaluate the butyrophilin gene family expression in human milk fat globule membrane.". Proteomics 2 (7): 850–6. doi:10.1002/1615-9861(200207)2:7<850::AID-PROT850>3.0.CO;2-C. PMID 12124930. 
  • Rhodes DA, Stammers M, Malcherek G, et al. (2001). "The cluster of BTN genes in the extended major histocompatibility complex.". Genomics 71 (3): 351–62. doi:10.1006/geno.2000.6406. PMID 11170752. 
  • Ruddy DA, Kronmal GS, Lee VK, et al. (1997). "A 1.1-Mb transcript map of the hereditary hemochromatosis locus.". Genome Res. 7 (5): 441–56. PMID 9149941. 
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