BTLA

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B and T lymphocyte attenuator
PDB rendering based on 2aw2.
Available structures: 2aw2
Identifiers
Symbol(s) BTLA; BTLA1; CD272; FLJ16065; MGC129743
External IDs OMIM: 607925 MGI: 2658978 HomoloGene: 52233
Orthologs
Human Mouse
Entrez 151888 208154
Ensembl ENSG00000186265 ENSMUSG00000052013
Uniprot Q7Z6A9 Q32MV8
Refseq NM_181780 (mRNA)
NP_861445 (protein)		 NM_001037719 (mRNA)
NP_001032808 (protein)
Location Chr 3: 113.67 - 113.7 Mb Chr 16: 45.14 - 45.17 Mb
Pubmed search [1] [2]

B and T lymphocyte attenuator, also known as BTLA, is a human gene.[1] BTLA has also been designated as CD272 (cluster of differentiation 272).

BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 (MIM 600244) and CTLA4 (MIM 123890), BTLA interacts with a B7 homolog, B7H4.[supplied by OMIM][1] However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family (TNF) receptors, not just the B7 family of cell surface receptors. BTLA is a ligand for tumour necrosis factor (ligand) superfamily, member 14 (TNFSF14), also known as herpes virus etry mdiator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.

[edit] References

  1. ^ a b Entrez Gene: BTLA B and T lymphocyte associated.

[edit] Further reading

  • Pao LI, Bedzyk WD, Persin C, Cambier JC (1997). "Molecular targets of CD45 in B cell antigen receptor signal transduction.". J. Immunol. 158 (3): 1116–24. PMID 9013950. 
  • Pao LI, Cambier JC (1997). "Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells.". J. Immunol. 158 (6): 2663–9. PMID 9058799. 
  • Vilen BJ, Famiglietti SJ, Carbone AM, et al. (1997). "B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation.". J. Immunol. 159 (1): 231–43. PMID 9200459. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Watanabe N, Gavrieli M, Sedy JR, et al. (2003). "BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.". Nat. Immunol. 4 (7): 670–9. doi:10.1038/ni944. PMID 12796776. 
  • Gavrieli M, Watanabe N, Loftin SK, et al. (2004). "Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2.". Biochem. Biophys. Res. Commun. 312 (4): 1236–43. PMID 14652006. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Sedy JR, Gavrieli M, Potter KG, et al. (2005). "B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator.". Nat. Immunol. 6 (1): 90–8. doi:10.1038/ni1144. PMID 15568026. 
  • Gonzalez LC, Loyet KM, Calemine-Fenaux J, et al. (2005). "A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator.". Proc. Natl. Acad. Sci. U.S.A. 102 (4): 1116–21. doi:10.1073/pnas.0409071102. PMID 15647361. 
  • Cheung TC, Humphreys IR, Potter KG, et al. (2005). "Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway.". Proc. Natl. Acad. Sci. U.S.A. 102 (37): 13218–23. doi:10.1073/pnas.0506172102. PMID 16131544. 
  • Compaan DM, Gonzalez LC, Tom I, et al. (2006). "Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex.". J. Biol. Chem. 280 (47): 39553–61. doi:10.1074/jbc.M507629200. PMID 16169851. 
  • Otsuki N, Kamimura Y, Hashiguchi M, Azuma M (2006). "Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells.". Biochem. Biophys. Res. Commun. 344 (4): 1121–7. doi:10.1016/j.bbrc.2006.03.242. PMID 16643847. 
  • Wang XF, Chen YJ, Wang Q, et al. (2007). "Distinct expression and inhibitory function of B and T lymphocyte attenuator on human T cells.". Tissue Antigens 69 (2): 145–53. doi:10.1111/j.1399-0039.2006.00710.x. PMID 17257317. 

[edit] External links

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350